Non-neutralizing monoclonal antibody targeting VP2 EF loop of Coxsackievirus A16 can protect mice from lethal attack via Fc-dependent effector mechanism

Coxsackievirus A16 (CA16), a main causative agent of hand, foot, and mouth disease (HFMD), has become a serious public health concern in the Asia-Pacific region. Here, we generated an anti-CA16 monoclonal antibody, DMA2017, derived from an epidemic strain CA16. Surprisingly, although DMA2017 could n...

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Detalles Bibliográficos
Autores principales: Du, Ruixiao, An, Chaoqiang, Yao, Xin, Wang, Yiping, Wang, Ge, Gao, Fan, Bian, Lianlian, Hu, Yalin, Liu, Siyuan, Zhao, Qiaohui, Mao, Qunying, Liang, Zhenglun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Non-Neutralizing Protective Antibodies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788719/
https://www.ncbi.nlm.nih.gov/pubmed/36395069
http://dx.doi.org/10.1080/22221751.2022.2149352

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