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Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation

The 26S proteasome recognizes thousands of appropriate protein substrates in eukaryotic cells through attached ubiquitin chains and uses its adenosine triphosphatase (ATPase) motor for mechanical unfolding and translocation into a proteolytic chamber. Here, we used single-molecule Förster resonance...

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Detalles Bibliográficos
Autores principales:	Jonsson, Erik, Htet, Zaw Min, Bard, Jared A. M., Dong, Ken C., Martin, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788759/ https://www.ncbi.nlm.nih.gov/pubmed/36563145 http://dx.doi.org/10.1126/sciadv.add9520

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