Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

It is urgent to develop more effective mRNA vaccines against the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing to the immune escape. Here, we constructed a novel mRNA delivery system [IC8/Mn lipid nanoparticles (IC8/Mn LNPs)]with high immunogenicity, via introd...

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Detalles Bibliográficos
Autores principales: Fan, Na, Chen, Kepan, Zhu, Rong, Zhang, Zhongwei, Huang, Hai, Qin, Shugang, Zheng, Qian, He, Zhongshan, He, Xi, Xiao, Wen, Zhang, Yupei, Gu, Yongjun, Zhao, Changchun, Liu, Yongmei, Jiang, Xin, Li, Shuaicheng, Wei, Yuquan, Song, Xiangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788765/
https://www.ncbi.nlm.nih.gov/pubmed/36563159
http://dx.doi.org/10.1126/sciadv.abq3500

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