The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) egress occurs by lysosomal exocytosis. We show that the Spike D614G mutation enhances Spike trafficking to lysosomes, drives Spike-mediated reprogramming of lysosomes, and reduces cell surface Spike expression by ~3-fold. D614G is not a hu...

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Detalles Bibliográficos
Autores principales: Guo, Chenxu, Tsai, Shang-Jui, Ai, Yiwei, Li, Maggie, Anaya, Eduardo, Pekosz, Andrew, Cox, Andrea, Gould, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788772/
https://www.ncbi.nlm.nih.gov/pubmed/36563151
http://dx.doi.org/10.1126/sciadv.ade5085

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