An orbitofrontal cortex–anterior insular cortex circuit gates compulsive cocaine use

Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent substance use despite adverse consequences. However, little is known about the neural circuit mechanisms behind this behavior. Using a footshock-punished cocaine self-administration procedure, we found individu...

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Detalles Bibliográficos
Autores principales: Chen, Yang, Wang, Guibin, Zhang, Wen, Han, Ying, Zhang, Libo, Xu, Hubo, Meng, Shiqiu, Lu, Lin, Xue, Yanxue, Shi, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788779/
https://www.ncbi.nlm.nih.gov/pubmed/36563158
http://dx.doi.org/10.1126/sciadv.abq5745

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