Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice

Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast cancer could identify new mechanisms of anthracycline cardiac toxicity. We measured changes in 1317 proteins in anthracycli...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Lane, Sarah, Lall, Rahul, Russo, Michele, Farrell, Laurie, Debreli Coskun, Melis, Curtin, Casie, Araujo-Gutierrez, Raquel, Scherrer-Crosbie, Marielle, Trachtenberg, Barry H., Kim, Jonghan, Tolosano, Emanuela, Ghigo, Alessandra, Gerszten, Robert E., Asnani, Aarti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788780/
https://www.ncbi.nlm.nih.gov/pubmed/36563141
http://dx.doi.org/10.1126/sciadv.adc9245

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