The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila

Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1 in mammals to execute the pathological...

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Detalles Bibliográficos
Autores principales: Llobet Rosell, Arnau, Paglione, Maria, Gilley, Jonathan, Kocia, Magdalena, Perillo, Giulia, Gasparrini, Massimiliano, Cialabrini, Lucia, Raffaelli, Nadia, Angeletti, Carlo, Orsomando, Giuseppe, Wu, Pei-Hsuan, Coleman, Michael P, Loreto, Andrea, Neukomm, Lukas Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788811/
https://www.ncbi.nlm.nih.gov/pubmed/36476387
http://dx.doi.org/10.7554/eLife.80245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788811/
https://www.ncbi.nlm.nih.gov/pubmed/36476387
http://dx.doi.org/10.7554/eLife.80245

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