Cargando…

The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila

Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1 in mammals to execute the pathological...

Descripción completa

Detalles Bibliográficos
Autores principales:	Llobet Rosell, Arnau, Paglione, Maria, Gilley, Jonathan, Kocia, Magdalena, Perillo, Giulia, Gasparrini, Massimiliano, Cialabrini, Lucia, Raffaelli, Nadia, Angeletti, Carlo, Orsomando, Giuseppe, Wu, Pei-Hsuan, Coleman, Michael P, Loreto, Andrea, Neukomm, Lukas Jakob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788811/ https://www.ncbi.nlm.nih.gov/pubmed/36476387 http://dx.doi.org/10.7554/eLife.80245

Ejemplares similares

Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis
por: Herrmann, Kelsey A., et al.
Publicado: (2022)

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
por: Angeletti, Carlo, et al.
Publicado: (2022)

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
por: Gilley, Jonathan, et al.
Publicado: (2015)

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
por: Di Stefano, M, et al.
Publicado: (2015)

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
por: Loreto, Andrea, et al.
Publicado: (2021)

Axon death signalling in Wallerian degeneration among species and in disease
por: Llobet Rosell, Arnau, et al.
Publicado: (2019)

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
por: Loreto, Andrea, et al.
Publicado: (2020)

Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases
por: Cialabrini, Lucia, et al.
Publicado: (2013)

Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival
por: Ademi, Mirlinda, et al.
Publicado: (2022)

Safety Evaluation for Restorin® NMN, a NAD+ Precursor
por: Turner, John, et al.
Publicado: (2021)

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
por: Gould, Stacey Anne, et al.
Publicado: (2021)

Characterization of Two NMN Deamidase Mutants as Possible Probes for an NMN Biosensor
por: Camarca, Alessandra, et al.
Publicado: (2021)

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion
por: Sasaki, Yo, et al.
Publicado: (2016)

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
por: Sverkeli, Lars Jansen, et al.
Publicado: (2021)

Differences in Extracellular NAD(+) and NMN Metabolism on the Surface of Vascular Endothelial Cells
por: Jablonska, Patrycja, et al.
Publicado: (2022)

Enzymology of extracellular NAD metabolism
por: Gasparrini, Massimiliano, et al.
Publicado: (2021)

Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy
por: Gilley, Jonathan, et al.
Publicado: (2017)

Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD(+) Biosynthesis in Whole Mice
por: Sauve, Anthony A., et al.
Publicado: (2023)

A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death
por: Zhao, Zhi Ying, et al.
Publicado: (2019)

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice
por: Fazal, Shaline V., et al.
Publicado: (2023)

Treatment of SARS-CoV-2-induced pneumonia with NAD(+) and NMN in two mouse models
por: Jiang, Yisheng, et al.
Publicado: (2022)

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health
por: Alegre, Gabriela Fabiana Soares, et al.
Publicado: (2023)

Multifaceted roles of SARM1 in axon degeneration and signaling
por: Waller, Thomas J., et al.
Publicado: (2022)

Distinct developmental and degenerative functions of SARM1 require NAD(+) hydrolase activity
por: Brace, E. J., et al.
Publicado: (2022)

SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
por: Ketschek, Andrea, et al.
Publicado: (2022)

TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration
por: Czech, Victoria L, et al.
Publicado: (2023)

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD(+) and NMN levels
por: Chini, Claudia C.S., et al.
Publicado: (2020)

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues
por: Mori, Valerio, et al.
Publicado: (2014)

Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies
por: Sundaramoorthy, Vinod, et al.
Publicado: (2020)

A good gut feeling on Sarm1-mediated axon degeneration
por: von Saucken, Victoria E., et al.
Publicado: (2021)

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease
por: Lai, Meng-Yu, et al.
Publicado: (2022)

A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration
por: Loring, Heather S, et al.
Publicado: (2021)

Small Molecule SARM1 Inhibitors Recapitulate the SARM1(−/−) Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
por: Hughes, Robert O., et al.
Publicado: (2021)

SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection
por: Crawford, Colin L., et al.
Publicado: (2022)

Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2
por: Hasegawa, Kazuhiro, et al.
Publicado: (2022)

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
por: Yang, Sen, et al.
Publicado: (2023)

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
por: Geisler, Stefanie, et al.
Publicado: (2019)

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
por: Ko, Kwang Woo, et al.
Publicado: (2020)

Sarm1 activation produces cADPR to increase intra-axonal Ca(++) and promote axon degeneration in PIPN
por: Li, Yihang, et al.
Publicado: (2021)

Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo
por: Milde, Stefan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_uk14la9rfi12v7gri3q11k9qvn