Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization

OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B, encoding osteoprotegerin (OPG) with additional 19 amino acids at its C-terminus (OPG-XL), causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in chond...

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Detalles Bibliográficos
Autores principales: Rodríguez Ruiz, Alejandro, van Hoolwerff, Marcella, Sprangers, Sara, Suchiman, Eka, Schoenmaker, Ton, Dibbets-Schneider, Petra, Bloem, Johan L, Nelissen, Rob G H H, Freund, Christian, Mummery, Christine, Everts, Vincent, de Vries, Teun J, Ramos, Yolande F M, Meulenbelt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788812/
https://www.ncbi.nlm.nih.gov/pubmed/35412619
http://dx.doi.org/10.1093/rheumatology/keac232

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