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Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes

OBJECTIVES: To investigate whether the deiodinase inhibitor iopanoic acid (IOP) has chondroprotective properties, a mechanical stress induced model of human aged explants was used to test both repeated dosing and slow release of IOP. METHODS: Human osteochondral explants subjected to injurious mecha...

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Detalles Bibliográficos
Autores principales:	Houtman, Evelyn, Tuerlings, Margo, Suchiman, H Eka D, Lakenberg, Nico, Cornelis, Frederique M F, Mei, Hailiang, Broekhuis, Demiën, Nelissen, Rob G H H, Coutinho de Almeida, Rodrigo, Ramos, Yolande F M, Lories, Rik J, Cruz, Luis J, Meulenbelt, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788824/ https://www.ncbi.nlm.nih.gov/pubmed/35383365 http://dx.doi.org/10.1093/rheumatology/keac202

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