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Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles

We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a dela...

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Autores principales: Touizer, Emma, Alrubayyi, Aljawharah, Ford, Rosemarie, Hussain, Noshin, Gerber, Pehuén Pereyra, Shum, Hiu-Long, Rees-Spear, Chloe, Muir, Luke, Gea-Mallorquí, Ester, Kopycinski, Jakub, Jankovic, Dylan, Jeffery-Smith, Anna, Pinder, Christopher L., Fox, Thomas A., Williams, Ian, Mullender, Claire, Maan, Irfaan, Waters, Laura, Johnson, Margaret, Madge, Sara, Youle, Michael, Barber, Tristan J., Burns, Fiona, Kinloch, Sabine, Rowland-Jones, Sarah, Gilson, Richard, Matheson, Nicholas J., Morris, Emma, Peppa, Dimitra, McCoy, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788849/
https://www.ncbi.nlm.nih.gov/pubmed/36590902
http://dx.doi.org/10.1016/j.isci.2022.105862
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author Touizer, Emma
Alrubayyi, Aljawharah
Ford, Rosemarie
Hussain, Noshin
Gerber, Pehuén Pereyra
Shum, Hiu-Long
Rees-Spear, Chloe
Muir, Luke
Gea-Mallorquí, Ester
Kopycinski, Jakub
Jankovic, Dylan
Jeffery-Smith, Anna
Pinder, Christopher L.
Fox, Thomas A.
Williams, Ian
Mullender, Claire
Maan, Irfaan
Waters, Laura
Johnson, Margaret
Madge, Sara
Youle, Michael
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Rowland-Jones, Sarah
Gilson, Richard
Matheson, Nicholas J.
Morris, Emma
Peppa, Dimitra
McCoy, Laura E.
author_facet Touizer, Emma
Alrubayyi, Aljawharah
Ford, Rosemarie
Hussain, Noshin
Gerber, Pehuén Pereyra
Shum, Hiu-Long
Rees-Spear, Chloe
Muir, Luke
Gea-Mallorquí, Ester
Kopycinski, Jakub
Jankovic, Dylan
Jeffery-Smith, Anna
Pinder, Christopher L.
Fox, Thomas A.
Williams, Ian
Mullender, Claire
Maan, Irfaan
Waters, Laura
Johnson, Margaret
Madge, Sara
Youle, Michael
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Rowland-Jones, Sarah
Gilson, Richard
Matheson, Nicholas J.
Morris, Emma
Peppa, Dimitra
McCoy, Laura E.
author_sort Touizer, Emma
collection PubMed
description We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs). Improved neutralization breadth was seen against the Omicron variant (BA.1) after the third vaccine dose in PLWH but lower nAb responses persisted and were associated with global MBC dysfunction. In contrast, SARS-CoV-2 vaccination induced robust T cell responses that cross-recognized variants in PLWH. Strikingly, individuals with low or absent neutralization had detectable functional T cell responses. These PLWH had reduced numbers of circulating T follicular helper cells and an enriched population of CXCR3(+)CD127(+)CD8(+)T cells after two doses of SARS-CoV-2 vaccination.
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spelling pubmed-97888492022-12-27 Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles Touizer, Emma Alrubayyi, Aljawharah Ford, Rosemarie Hussain, Noshin Gerber, Pehuén Pereyra Shum, Hiu-Long Rees-Spear, Chloe Muir, Luke Gea-Mallorquí, Ester Kopycinski, Jakub Jankovic, Dylan Jeffery-Smith, Anna Pinder, Christopher L. Fox, Thomas A. Williams, Ian Mullender, Claire Maan, Irfaan Waters, Laura Johnson, Margaret Madge, Sara Youle, Michael Barber, Tristan J. Burns, Fiona Kinloch, Sabine Rowland-Jones, Sarah Gilson, Richard Matheson, Nicholas J. Morris, Emma Peppa, Dimitra McCoy, Laura E. iScience Article We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs). Improved neutralization breadth was seen against the Omicron variant (BA.1) after the third vaccine dose in PLWH but lower nAb responses persisted and were associated with global MBC dysfunction. In contrast, SARS-CoV-2 vaccination induced robust T cell responses that cross-recognized variants in PLWH. Strikingly, individuals with low or absent neutralization had detectable functional T cell responses. These PLWH had reduced numbers of circulating T follicular helper cells and an enriched population of CXCR3(+)CD127(+)CD8(+)T cells after two doses of SARS-CoV-2 vaccination. Elsevier 2022-12-24 /pmc/articles/PMC9788849/ /pubmed/36590902 http://dx.doi.org/10.1016/j.isci.2022.105862 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Touizer, Emma
Alrubayyi, Aljawharah
Ford, Rosemarie
Hussain, Noshin
Gerber, Pehuén Pereyra
Shum, Hiu-Long
Rees-Spear, Chloe
Muir, Luke
Gea-Mallorquí, Ester
Kopycinski, Jakub
Jankovic, Dylan
Jeffery-Smith, Anna
Pinder, Christopher L.
Fox, Thomas A.
Williams, Ian
Mullender, Claire
Maan, Irfaan
Waters, Laura
Johnson, Margaret
Madge, Sara
Youle, Michael
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Rowland-Jones, Sarah
Gilson, Richard
Matheson, Nicholas J.
Morris, Emma
Peppa, Dimitra
McCoy, Laura E.
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title_full Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title_fullStr Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title_full_unstemmed Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title_short Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles
title_sort attenuated humoral responses in hiv after sars-cov-2 vaccination linked to b cell defects and altered immune profiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788849/
https://www.ncbi.nlm.nih.gov/pubmed/36590902
http://dx.doi.org/10.1016/j.isci.2022.105862
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