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Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

OBJECTIVE: To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc). METHODS: In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated...

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Autores principales: Spinella, Amelia, de Pinto, Marco, Baraldi, Carlo, Galluzzo, Claudio, Testoni, Sofia, Lumetti, Federica, Parenti, Luca, Guerzoni, Simona, Salvarani, Carlo, Giuggioli, Dilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788924/
https://www.ncbi.nlm.nih.gov/pubmed/36537770
http://dx.doi.org/10.1097/01.ASW.0000891856.08360.61
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author Spinella, Amelia
de Pinto, Marco
Baraldi, Carlo
Galluzzo, Claudio
Testoni, Sofia
Lumetti, Federica
Parenti, Luca
Guerzoni, Simona
Salvarani, Carlo
Giuggioli, Dilia
author_facet Spinella, Amelia
de Pinto, Marco
Baraldi, Carlo
Galluzzo, Claudio
Testoni, Sofia
Lumetti, Federica
Parenti, Luca
Guerzoni, Simona
Salvarani, Carlo
Giuggioli, Dilia
author_sort Spinella, Amelia
collection PubMed
description OBJECTIVE: To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc). METHODS: In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment. RESULTS: Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants’ total hours of sleep. Patients in the control group more frequently required additional analgesic therapy. CONCLUSIONS: Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.
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spelling pubmed-97889242022-12-28 Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review Spinella, Amelia de Pinto, Marco Baraldi, Carlo Galluzzo, Claudio Testoni, Sofia Lumetti, Federica Parenti, Luca Guerzoni, Simona Salvarani, Carlo Giuggioli, Dilia Adv Skin Wound Care Original Investigations OBJECTIVE: To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc). METHODS: In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment. RESULTS: Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants’ total hours of sleep. Patients in the control group more frequently required additional analgesic therapy. CONCLUSIONS: Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc. Lippincott Williams & Wilkins 2023-01 2022-12-14 /pmc/articles/PMC9788924/ /pubmed/36537770 http://dx.doi.org/10.1097/01.ASW.0000891856.08360.61 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Investigations
Spinella, Amelia
de Pinto, Marco
Baraldi, Carlo
Galluzzo, Claudio
Testoni, Sofia
Lumetti, Federica
Parenti, Luca
Guerzoni, Simona
Salvarani, Carlo
Giuggioli, Dilia
Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title_full Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title_fullStr Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title_full_unstemmed Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title_short Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review
title_sort topical cannabidiol in the treatment of digital ulcers in patients with scleroderma: comparative analysis and literature review
topic Original Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788924/
https://www.ncbi.nlm.nih.gov/pubmed/36537770
http://dx.doi.org/10.1097/01.ASW.0000891856.08360.61
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