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Durvalumab Plus Olaparib in Previously Untreated, Platinum-Ineligible Patients With Metastatic Urothelial Carcinoma: A Multicenter, Randomized, Phase II Trial (BAYOU)
Homologous recombination repair gene mutations (HRRm) are common in urothelial carcinoma (UC), rendering tumor cells sensitive to poly (ADP-ribose) polymerase (PARP) inhibition. We assessed efficacy and safety of durvalumab (anti–programmed cell death ligand-1) plus olaparib (PARP inhibitor) in pati...
Autores principales: | Rosenberg, Jonathan E., Park, Se Hoon, Kozlov, Vadim, Dao, Tu V., Castellano, Daniel, Li, Jian-Ri, Mukherjee, Som D., Howells, Kathryn, Dry, Hannah, Lanasa, Mark C., Stewart, Ross, Bajorin, Dean F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788981/ https://www.ncbi.nlm.nih.gov/pubmed/35737919 http://dx.doi.org/10.1200/JCO.22.00205 |
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