Cargando…

Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?

Medical detection dogs have a high potential for use as alternative diagnostic tools not only for organic diseases, but also for infectious diseases. However, new variants emerging over time may affect the accuracy and sensitivity of diagnostic methods including medical detection dogs in case of vir...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozgur-Buyukatalay, Elcin, Demirbas, Yasemin Salgirli, Bozdayi, Gulendam, Kismali, Gorkem, Ilhan, Mustafa Necmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788989/
https://www.ncbi.nlm.nih.gov/pubmed/36589678
http://dx.doi.org/10.1016/j.applanim.2022.105825
_version_ 1784858876940648448
author Ozgur-Buyukatalay, Elcin
Demirbas, Yasemin Salgirli
Bozdayi, Gulendam
Kismali, Gorkem
Ilhan, Mustafa Necmi
author_facet Ozgur-Buyukatalay, Elcin
Demirbas, Yasemin Salgirli
Bozdayi, Gulendam
Kismali, Gorkem
Ilhan, Mustafa Necmi
author_sort Ozgur-Buyukatalay, Elcin
collection PubMed
description Medical detection dogs have a high potential for use as alternative diagnostic tools not only for organic diseases, but also for infectious diseases. However, new variants emerging over time may affect the accuracy and sensitivity of diagnostic methods including medical detection dogs in case of viral pandemics. To the best of our knowledge, this is a pioneer study aimed to investigate diagnostic performances and generalization ability of SARS-CoV-2 detection dogs against the new variant after being trained with the original virus. Two SARS-CoV-2 detection dogs were used in this study. In total, 1002 samples including the Omicron variant were introduced to the dogs using a double-blinded design. Two different refresher training sessions were conducted to train the dogs to identify the scent of the Omicron variant. In the first refreshment training, mixed samples (original virus and Omicron variant) were used. The diagnostic performances of the dogs were significantly increased only after the second refreshment training where only the Omicron variant was introduced. This study illustrates that diagnostic performances of SARS-CoV-2 detection dogs were not consistent over time with the emerging new variants. Thus, refreshment training with new variant(s) should be conducted with every new variant which may affect the diagnostic performances of those dogs in such infectious outbreaks.
format Online
Article
Text
id pubmed-9788989
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-97889892022-12-27 Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time? Ozgur-Buyukatalay, Elcin Demirbas, Yasemin Salgirli Bozdayi, Gulendam Kismali, Gorkem Ilhan, Mustafa Necmi Appl Anim Behav Sci Article Medical detection dogs have a high potential for use as alternative diagnostic tools not only for organic diseases, but also for infectious diseases. However, new variants emerging over time may affect the accuracy and sensitivity of diagnostic methods including medical detection dogs in case of viral pandemics. To the best of our knowledge, this is a pioneer study aimed to investigate diagnostic performances and generalization ability of SARS-CoV-2 detection dogs against the new variant after being trained with the original virus. Two SARS-CoV-2 detection dogs were used in this study. In total, 1002 samples including the Omicron variant were introduced to the dogs using a double-blinded design. Two different refresher training sessions were conducted to train the dogs to identify the scent of the Omicron variant. In the first refreshment training, mixed samples (original virus and Omicron variant) were used. The diagnostic performances of the dogs were significantly increased only after the second refreshment training where only the Omicron variant was introduced. This study illustrates that diagnostic performances of SARS-CoV-2 detection dogs were not consistent over time with the emerging new variants. Thus, refreshment training with new variant(s) should be conducted with every new variant which may affect the diagnostic performances of those dogs in such infectious outbreaks. Elsevier B.V. 2023-01 2022-12-24 /pmc/articles/PMC9788989/ /pubmed/36589678 http://dx.doi.org/10.1016/j.applanim.2022.105825 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ozgur-Buyukatalay, Elcin
Demirbas, Yasemin Salgirli
Bozdayi, Gulendam
Kismali, Gorkem
Ilhan, Mustafa Necmi
Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title_full Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title_fullStr Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title_full_unstemmed Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title_short Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?
title_sort is diagnostic performance of sars-cov-2 detection dogs reduced -due to virus variation- over the time?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788989/
https://www.ncbi.nlm.nih.gov/pubmed/36589678
http://dx.doi.org/10.1016/j.applanim.2022.105825
work_keys_str_mv AT ozgurbuyukatalayelcin isdiagnosticperformanceofsarscov2detectiondogsreducedduetovirusvariationoverthetime
AT demirbasyaseminsalgirli isdiagnosticperformanceofsarscov2detectiondogsreducedduetovirusvariationoverthetime
AT bozdayigulendam isdiagnosticperformanceofsarscov2detectiondogsreducedduetovirusvariationoverthetime
AT kismaligorkem isdiagnosticperformanceofsarscov2detectiondogsreducedduetovirusvariationoverthetime
AT ilhanmustafanecmi isdiagnosticperformanceofsarscov2detectiondogsreducedduetovirusvariationoverthetime