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Reproductive axis ageing and fertility in men

Compared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as sp...

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Autores principales: Martins da Silva, Sarah, Anderson, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789007/
https://www.ncbi.nlm.nih.gov/pubmed/36322295
http://dx.doi.org/10.1007/s11154-022-09759-0
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author Martins da Silva, Sarah
Anderson, Richard A
author_facet Martins da Silva, Sarah
Anderson, Richard A
author_sort Martins da Silva, Sarah
collection PubMed
description Compared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as spermatogenesis. There is a decline in sexual function as men age, with a dramatic increase in the prevalence of erectile dysfunction after the age of 40, which is a marker for both clinically evident as well as covert coronary artery disease. Despite a quantitative decline in spermatogenesis and reduced fecundability, the male potential for fertility persists throughout adult life, however there are also increasingly recognised alterations in sperm quality and function with significant implications for offspring health. These changes are relevant to both natural and medically assisted conception.
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spelling pubmed-97890072022-12-25 Reproductive axis ageing and fertility in men Martins da Silva, Sarah Anderson, Richard A Rev Endocr Metab Disord Article Compared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as spermatogenesis. There is a decline in sexual function as men age, with a dramatic increase in the prevalence of erectile dysfunction after the age of 40, which is a marker for both clinically evident as well as covert coronary artery disease. Despite a quantitative decline in spermatogenesis and reduced fecundability, the male potential for fertility persists throughout adult life, however there are also increasingly recognised alterations in sperm quality and function with significant implications for offspring health. These changes are relevant to both natural and medically assisted conception. Springer US 2022-11-02 2022 /pmc/articles/PMC9789007/ /pubmed/36322295 http://dx.doi.org/10.1007/s11154-022-09759-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Martins da Silva, Sarah
Anderson, Richard A
Reproductive axis ageing and fertility in men
title Reproductive axis ageing and fertility in men
title_full Reproductive axis ageing and fertility in men
title_fullStr Reproductive axis ageing and fertility in men
title_full_unstemmed Reproductive axis ageing and fertility in men
title_short Reproductive axis ageing and fertility in men
title_sort reproductive axis ageing and fertility in men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789007/
https://www.ncbi.nlm.nih.gov/pubmed/36322295
http://dx.doi.org/10.1007/s11154-022-09759-0
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