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Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression

Human melanocytic nevi (moles) result from a brief period of clonal expansion of melanocytes. As a cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter a senescent state of stable cell cycle arrest. Senescent melanocytes can persist for months in mice a...

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Detalles Bibliográficos
Autores principales: Kohli, Jaskaren, Ge, Chen, Fitsiou, Eleni, Doepner, Miriam, Brandenburg, Simone M., Faller, William J., Ridky, Todd W., Demaria, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789033/
https://www.ncbi.nlm.nih.gov/pubmed/36564381
http://dx.doi.org/10.1038/s41467-022-35657-9