Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations

Mutation-mediated treatment resistance is one of the primary challenges for modern antibiotic and anti-cancer therapy. Yet, many resistance mutations have a substantial fitness cost and are subject to purifying selection. How emerging resistant lineages may escape purifying selection via subsequent...

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Detalles Bibliográficos
Autores principales: Aif, Serhii, Appold, Nico, Kampman, Lucas, Hallatschek, Oskar, Kayser, Jona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789051/
https://www.ncbi.nlm.nih.gov/pubmed/36564390
http://dx.doi.org/10.1038/s41467-022-35484-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789051/
https://www.ncbi.nlm.nih.gov/pubmed/36564390
http://dx.doi.org/10.1038/s41467-022-35484-y

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