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Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations
Mutation-mediated treatment resistance is one of the primary challenges for modern antibiotic and anti-cancer therapy. Yet, many resistance mutations have a substantial fitness cost and are subject to purifying selection. How emerging resistant lineages may escape purifying selection via subsequent...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789051/ https://www.ncbi.nlm.nih.gov/pubmed/36564390 http://dx.doi.org/10.1038/s41467-022-35484-y |