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Association of body composition fat parameters and breast density in mammography by menopausal status

We investigated the relationship between body fat-driven obesity and breast fat density in mammography according to menopausal status. We retrospectively analyzed 8537 women (premenopausal, n = 4351; postmenopausal, n = 4186). Body fat parameters included BMI (body mass index), waist circumference (...

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Autores principales: Chu, Ajung, Sung, Pamela, Lee, Jongyoon, Cheun, Jong-Ho, Hwang, Ki-Tae, Lee, Kooklae, Kim, Jiwon, Jeong, Jibong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789058/
https://www.ncbi.nlm.nih.gov/pubmed/36564447
http://dx.doi.org/10.1038/s41598-022-26839-y
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author Chu, Ajung
Sung, Pamela
Lee, Jongyoon
Cheun, Jong-Ho
Hwang, Ki-Tae
Lee, Kooklae
Kim, Jiwon
Jeong, Jibong
author_facet Chu, Ajung
Sung, Pamela
Lee, Jongyoon
Cheun, Jong-Ho
Hwang, Ki-Tae
Lee, Kooklae
Kim, Jiwon
Jeong, Jibong
author_sort Chu, Ajung
collection PubMed
description We investigated the relationship between body fat-driven obesity and breast fat density in mammography according to menopausal status. We retrospectively analyzed 8537 women (premenopausal, n = 4351; postmenopausal, n = 4186). Body fat parameters included BMI (body mass index), waist circumference (WC), waist-hip ratio (WHR), fat mass index (FMI), Percentage of body fat (PBF), and visceral fat area (VFA). Body fat-driven obesity was defined as follows: overall obesity, BMI ≥ 25 kg/m(2); central obesity, WC > 85 cm; abdominal obesity, WHR > 0.85; excessive FMI, the highest quartile (Q4) of FMI; excessive PBF, the highest quartile (Q4) of VFA; visceral obesity, and the highest quartile (Q4) of VFA). Breast density was classified according to BI-RADS (grade a, b, c, and d), which defined as an ordinal scale (grade a = 1, grade b = 2, grade c = 3, and grade d = 4). All body fat-driven obesity parameters were negatively associated with the grade of breast density in both groups of women (p < 0.001): The more fatty parameters are, the less dense breast is. In multivariable binary logistic regression, all body fat-driven obesity parameters also showed a negative association with grade d density (vs. grade a, b, or c). In premenopausal women, BMI was a more associated parameter with grade d density than those of the other fat-driven parameters (OR 0.265, CI 0.204–0.344). In postmenopausal women, WC was more associated with grade d density than the others (OR 0.315, CI 0.239–0.416). We found that BMI, WC, WHR, FMI, PBF and VFA were negatively correlated with dense breast, and the association degree pattern between body fat-driven obesity and dense breast differs according to menopausal status.
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spelling pubmed-97890582022-12-25 Association of body composition fat parameters and breast density in mammography by menopausal status Chu, Ajung Sung, Pamela Lee, Jongyoon Cheun, Jong-Ho Hwang, Ki-Tae Lee, Kooklae Kim, Jiwon Jeong, Jibong Sci Rep Article We investigated the relationship between body fat-driven obesity and breast fat density in mammography according to menopausal status. We retrospectively analyzed 8537 women (premenopausal, n = 4351; postmenopausal, n = 4186). Body fat parameters included BMI (body mass index), waist circumference (WC), waist-hip ratio (WHR), fat mass index (FMI), Percentage of body fat (PBF), and visceral fat area (VFA). Body fat-driven obesity was defined as follows: overall obesity, BMI ≥ 25 kg/m(2); central obesity, WC > 85 cm; abdominal obesity, WHR > 0.85; excessive FMI, the highest quartile (Q4) of FMI; excessive PBF, the highest quartile (Q4) of VFA; visceral obesity, and the highest quartile (Q4) of VFA). Breast density was classified according to BI-RADS (grade a, b, c, and d), which defined as an ordinal scale (grade a = 1, grade b = 2, grade c = 3, and grade d = 4). All body fat-driven obesity parameters were negatively associated with the grade of breast density in both groups of women (p < 0.001): The more fatty parameters are, the less dense breast is. In multivariable binary logistic regression, all body fat-driven obesity parameters also showed a negative association with grade d density (vs. grade a, b, or c). In premenopausal women, BMI was a more associated parameter with grade d density than those of the other fat-driven parameters (OR 0.265, CI 0.204–0.344). In postmenopausal women, WC was more associated with grade d density than the others (OR 0.315, CI 0.239–0.416). We found that BMI, WC, WHR, FMI, PBF and VFA were negatively correlated with dense breast, and the association degree pattern between body fat-driven obesity and dense breast differs according to menopausal status. Nature Publishing Group UK 2022-12-23 /pmc/articles/PMC9789058/ /pubmed/36564447 http://dx.doi.org/10.1038/s41598-022-26839-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chu, Ajung
Sung, Pamela
Lee, Jongyoon
Cheun, Jong-Ho
Hwang, Ki-Tae
Lee, Kooklae
Kim, Jiwon
Jeong, Jibong
Association of body composition fat parameters and breast density in mammography by menopausal status
title Association of body composition fat parameters and breast density in mammography by menopausal status
title_full Association of body composition fat parameters and breast density in mammography by menopausal status
title_fullStr Association of body composition fat parameters and breast density in mammography by menopausal status
title_full_unstemmed Association of body composition fat parameters and breast density in mammography by menopausal status
title_short Association of body composition fat parameters and breast density in mammography by menopausal status
title_sort association of body composition fat parameters and breast density in mammography by menopausal status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789058/
https://www.ncbi.nlm.nih.gov/pubmed/36564447
http://dx.doi.org/10.1038/s41598-022-26839-y
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