PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis

Sepsis is a life-threatening syndrome with multi-organ dysfunction in critical care medicine. With the occurrence of sepsis-induced cardiomyopathy (SIC), characterized by reduced ventricular contractility, the mortality of sepsis is boosted to 70–90%. Pyruvate kinase M2 (PKM2) functions in a variety...

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Detalles Bibliográficos
Autores principales: Ni, Le, Lin, Bowen, Shen, Meiting, Li, Can, Hu, Lingjie, Fu, Fengmei, Chen, Lei, Yang, Jian, Shi, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789059/
https://www.ncbi.nlm.nih.gov/pubmed/36564378
http://dx.doi.org/10.1038/s41420-022-01287-9

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