Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease

In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically specific way, but the mechanisms underlying cystogenesis remain elusive. Here we show that subjecting organoids to fluid sh...

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Detalles Bibliográficos
Autores principales: Li, Sienna R., Gulieva, Ramila E., Helms, Louisa, Cruz, Nelly M., Vincent, Thomas, Fu, Hongxia, Himmelfarb, Jonathan, Freedman, Benjamin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789147/
https://www.ncbi.nlm.nih.gov/pubmed/36564419
http://dx.doi.org/10.1038/s41467-022-35537-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789147/
https://www.ncbi.nlm.nih.gov/pubmed/36564419
http://dx.doi.org/10.1038/s41467-022-35537-2

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