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The age-related pattern of inner retinal thickening is affected by myopia development and progression

The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in marmoset...

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Autores principales: Ablordeppey, Reynolds Kwame, Lin, Carol, Benavente-Perez, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789149/
https://www.ncbi.nlm.nih.gov/pubmed/36564498
http://dx.doi.org/10.1038/s41598-022-26598-w
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author Ablordeppey, Reynolds Kwame
Lin, Carol
Benavente-Perez, Alexandra
author_facet Ablordeppey, Reynolds Kwame
Lin, Carol
Benavente-Perez, Alexandra
author_sort Ablordeppey, Reynolds Kwame
collection PubMed
description The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in marmosets (Callithrix jacchus) induced with myopia continuously for 5.5 months compared to controls using spectral-domain optical coherence tomography. Cycloplegic refractive state (Rx), vitreous chamber depth (VCD) and retinal thickness were measured at baseline and after 3 and 5.5 months on thirteen marmosets: eight animals with lens-induced myopia and five untreated controls. The overall and individual retinal layer thickness in the central and mid-peripheral retina were obtained and compared between groups. Regression models were used to explore the extent to which VCD or Rx changes could predict the thickness changes observed. While the retinas of control marmosets thickened significantly over 5.5 months, marmosets with lens-induced myopia experienced less retinal thickening and thinning at times, mostly in the inner neuroretinal layers and the ganglion cell-inner plexiform layer. The regression models suggest that 90% of the growth and refractive changes observed could be predicted by the thickness changes in the near to mid peripheral retina. This study confirms the longitudinal effect that myopia has on the inner retina of a NHP model during the early stages of myopia development. The observed myopia-driven differences in inner retina thickness templates might represent early biomarkers of myopia progression and associated complications.
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spelling pubmed-97891492022-12-25 The age-related pattern of inner retinal thickening is affected by myopia development and progression Ablordeppey, Reynolds Kwame Lin, Carol Benavente-Perez, Alexandra Sci Rep Article The longitudinal effect of myopic eye growth on each individual retinal layer has not been described to date on an established non-human primate (NHP) model of myopia. We evaluated the changes experienced by the overall and individual central and mid-peripheral retinal thickness profiles in marmosets (Callithrix jacchus) induced with myopia continuously for 5.5 months compared to controls using spectral-domain optical coherence tomography. Cycloplegic refractive state (Rx), vitreous chamber depth (VCD) and retinal thickness were measured at baseline and after 3 and 5.5 months on thirteen marmosets: eight animals with lens-induced myopia and five untreated controls. The overall and individual retinal layer thickness in the central and mid-peripheral retina were obtained and compared between groups. Regression models were used to explore the extent to which VCD or Rx changes could predict the thickness changes observed. While the retinas of control marmosets thickened significantly over 5.5 months, marmosets with lens-induced myopia experienced less retinal thickening and thinning at times, mostly in the inner neuroretinal layers and the ganglion cell-inner plexiform layer. The regression models suggest that 90% of the growth and refractive changes observed could be predicted by the thickness changes in the near to mid peripheral retina. This study confirms the longitudinal effect that myopia has on the inner retina of a NHP model during the early stages of myopia development. The observed myopia-driven differences in inner retina thickness templates might represent early biomarkers of myopia progression and associated complications. Nature Publishing Group UK 2022-12-23 /pmc/articles/PMC9789149/ /pubmed/36564498 http://dx.doi.org/10.1038/s41598-022-26598-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ablordeppey, Reynolds Kwame
Lin, Carol
Benavente-Perez, Alexandra
The age-related pattern of inner retinal thickening is affected by myopia development and progression
title The age-related pattern of inner retinal thickening is affected by myopia development and progression
title_full The age-related pattern of inner retinal thickening is affected by myopia development and progression
title_fullStr The age-related pattern of inner retinal thickening is affected by myopia development and progression
title_full_unstemmed The age-related pattern of inner retinal thickening is affected by myopia development and progression
title_short The age-related pattern of inner retinal thickening is affected by myopia development and progression
title_sort age-related pattern of inner retinal thickening is affected by myopia development and progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789149/
https://www.ncbi.nlm.nih.gov/pubmed/36564498
http://dx.doi.org/10.1038/s41598-022-26598-w
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