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Thymoquinone played a protective role against tartrazine-induced hepatotoxicity

OBJECTIVE(S): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. MATERIALS AND METH...

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Autores principales: Demircigil, Nursena, Gul, Mehmet, Gokturk, Nurcan, Kustepe, Elif Kayhan, Bag, Harika Gozukara, Erdemli, Mehmet Erman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790050/
https://www.ncbi.nlm.nih.gov/pubmed/36594061
http://dx.doi.org/10.22038/IJBMS.2022.67341.14763
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author Demircigil, Nursena
Gul, Mehmet
Gokturk, Nurcan
Kustepe, Elif Kayhan
Bag, Harika Gozukara
Erdemli, Mehmet Erman
author_facet Demircigil, Nursena
Gul, Mehmet
Gokturk, Nurcan
Kustepe, Elif Kayhan
Bag, Harika Gozukara
Erdemli, Mehmet Erman
author_sort Demircigil, Nursena
collection PubMed
description OBJECTIVE(S): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. MATERIALS AND METHODS: 32 male Wistar albino rats were procured from İnönü University Experimental Animals Breeding and Research Center. The rats were randomly assigned to 4 equal groups: Control group, Thymoquinone group, Tartrazine group, and Thymoquinone + Tartrazine group. Rat liver tissue and blood samples were obtained and biochemical and histopathological examinations were conducted on the samples. RESULTS: Tartrazine administration increased the oxidant (malondialdehyde and superoxide dismutase) and oxidative stress index parameters (total oxidant status) in the liver tissue and decreased the antioxidant parameters (glutathione, glutathione peroxidase, catalase, and total antioxidant status) leading to histopathological problems (hematoxylin-eosin staining and Caspase-3 immunoreactivity) and inflammation (tumor necrosis factor-α and interleukin-6) in the serum samples. Thymoquinone, on the other hand, improved antioxidant and anti-inflammatory effects. CONCLUSION: At this time and dose, thymoquinone has a protective effect against tartrazine hepatotoxicity. Thymoquinone can be used as a protective agent against tartrazine toxicity.
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spelling pubmed-97900502023-01-01 Thymoquinone played a protective role against tartrazine-induced hepatotoxicity Demircigil, Nursena Gul, Mehmet Gokturk, Nurcan Kustepe, Elif Kayhan Bag, Harika Gozukara Erdemli, Mehmet Erman Iran J Basic Med Sci Original Article OBJECTIVE(S): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. MATERIALS AND METHODS: 32 male Wistar albino rats were procured from İnönü University Experimental Animals Breeding and Research Center. The rats were randomly assigned to 4 equal groups: Control group, Thymoquinone group, Tartrazine group, and Thymoquinone + Tartrazine group. Rat liver tissue and blood samples were obtained and biochemical and histopathological examinations were conducted on the samples. RESULTS: Tartrazine administration increased the oxidant (malondialdehyde and superoxide dismutase) and oxidative stress index parameters (total oxidant status) in the liver tissue and decreased the antioxidant parameters (glutathione, glutathione peroxidase, catalase, and total antioxidant status) leading to histopathological problems (hematoxylin-eosin staining and Caspase-3 immunoreactivity) and inflammation (tumor necrosis factor-α and interleukin-6) in the serum samples. Thymoquinone, on the other hand, improved antioxidant and anti-inflammatory effects. CONCLUSION: At this time and dose, thymoquinone has a protective effect against tartrazine hepatotoxicity. Thymoquinone can be used as a protective agent against tartrazine toxicity. Mashhad University of Medical Sciences 2023-01 /pmc/articles/PMC9790050/ /pubmed/36594061 http://dx.doi.org/10.22038/IJBMS.2022.67341.14763 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Demircigil, Nursena
Gul, Mehmet
Gokturk, Nurcan
Kustepe, Elif Kayhan
Bag, Harika Gozukara
Erdemli, Mehmet Erman
Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title_full Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title_fullStr Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title_full_unstemmed Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title_short Thymoquinone played a protective role against tartrazine-induced hepatotoxicity
title_sort thymoquinone played a protective role against tartrazine-induced hepatotoxicity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790050/
https://www.ncbi.nlm.nih.gov/pubmed/36594061
http://dx.doi.org/10.22038/IJBMS.2022.67341.14763
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