A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment

Hairy cell leukemia (HCL) is a rare disease of mature B-cell neoplasms. Its name comes from the hair-like strands surrounding the cytoplasm of the cells, which are observed on peripheral blood or bone marrow smears. Leukemic cells mainly involve the spleen, peripheral blood, and bone marrow. The cla...

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Detalles Bibliográficos
Autores principales: Tuan Nguyen, Tung, Thi Vinh Do, An, Phan Thi, Phuong, Lan Anh, Le, Vu, Minh Tam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790138/
https://www.ncbi.nlm.nih.gov/pubmed/36579239
http://dx.doi.org/10.7759/cureus.31882
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author Tuan Nguyen, Tung
Thi Vinh Do, An
Phan Thi, Phuong
Lan Anh, Le
Vu, Minh Tam
author_facet Tuan Nguyen, Tung
Thi Vinh Do, An
Phan Thi, Phuong
Lan Anh, Le
Vu, Minh Tam
author_sort Tuan Nguyen, Tung
collection PubMed
description Hairy cell leukemia (HCL) is a rare disease of mature B-cell neoplasms. Its name comes from the hair-like strands surrounding the cytoplasm of the cells, which are observed on peripheral blood or bone marrow smears. Leukemic cells mainly involve the spleen, peripheral blood, and bone marrow. The classical immunophenotyping of HCL includes overexpression of the B-cell surface antigens such as CD19, CD20, and CD22 and co-expression of CD25, CD103, CD11c, and CD123. Other markers including CD5, CD10, and CD38 are usually negative, in which CD38 is considered a poor prognostic factor. Herein, we report a case of HCL with atypical morphology and abnormal expression of both CD38 and CD10.
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spelling pubmed-97901382022-12-27 A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment Tuan Nguyen, Tung Thi Vinh Do, An Phan Thi, Phuong Lan Anh, Le Vu, Minh Tam Cureus Pathology Hairy cell leukemia (HCL) is a rare disease of mature B-cell neoplasms. Its name comes from the hair-like strands surrounding the cytoplasm of the cells, which are observed on peripheral blood or bone marrow smears. Leukemic cells mainly involve the spleen, peripheral blood, and bone marrow. The classical immunophenotyping of HCL includes overexpression of the B-cell surface antigens such as CD19, CD20, and CD22 and co-expression of CD25, CD103, CD11c, and CD123. Other markers including CD5, CD10, and CD38 are usually negative, in which CD38 is considered a poor prognostic factor. Herein, we report a case of HCL with atypical morphology and abnormal expression of both CD38 and CD10. Cureus 2022-11-25 /pmc/articles/PMC9790138/ /pubmed/36579239 http://dx.doi.org/10.7759/cureus.31882 Text en Copyright © 2022, Tuan Nguyen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Tuan Nguyen, Tung
Thi Vinh Do, An
Phan Thi, Phuong
Lan Anh, Le
Vu, Minh Tam
A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title_full A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title_fullStr A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title_full_unstemmed A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title_short A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment
title_sort case of atypical hairy cell leukemia with cd10+ and cd38+: diagnosis and treatment
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790138/
https://www.ncbi.nlm.nih.gov/pubmed/36579239
http://dx.doi.org/10.7759/cureus.31882
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