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Role of Chemokines and Inflammatory Cells in Respiratory Allergy

The idea of “one airway, one disease” has been gaining importance in the last decade. In the upper and lower airways, allergic mechanisms interact with each other. In the initial stage of respiratory allergic inflammation, allergens contact the respiratory epithelium, which produces chemokines and i...

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Autores principales: Bao, Youwei, Zhu, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790160/
https://www.ncbi.nlm.nih.gov/pubmed/36575714
http://dx.doi.org/10.2147/JAA.S395490
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author Bao, Youwei
Zhu, Xinhua
author_facet Bao, Youwei
Zhu, Xinhua
author_sort Bao, Youwei
collection PubMed
description The idea of “one airway, one disease” has been gaining importance in the last decade. In the upper and lower airways, allergic mechanisms interact with each other. In the initial stage of respiratory allergic inflammation, allergens contact the respiratory epithelium, which produces chemokines and inflammatory factors, which cause allergic reactions by binding to the corresponding receptors and chemotactic various inflammatory cells to reach the epithelium and tissues. It also drives inflammatory cells to activate and produce more inflammatory factors, thus producing a cascade amplification effect. Inflammatory cell aggregation and activation are very complex and interact with each other in a lattice structure. By blocking the action of various chemokines, inflammatory cell aggregation is reduced, and ultimately the symptoms of respiratory allergy are alleviated. Chemokines can serve as cues for coordinated recruitment of immune cells into and out of tissues, as well as directing the spatial organization of immune cells within tissues and cellular interactions. Chemokines are critical in directing immune cell migration and thus have an important role in the direction of respiratory allergy: however, chemokines are also involved in the production and recruitment of immune cells that contribute to respiratory allergy. In this article, linking the upper and lower respiratory tracts. We review the role of the chemokine system in the respiratory immune response and discuss how respiratory disease modulates overall chemokines to shape the type and outcome of the immune response to the treatment of respiratory allergic disease so that we can further deepen our knowledge of chemokines in the direction of respiratory allergy. In the future, we can do drug research and development based on this network structure and explore new research directions.
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spelling pubmed-97901602022-12-26 Role of Chemokines and Inflammatory Cells in Respiratory Allergy Bao, Youwei Zhu, Xinhua J Asthma Allergy Review The idea of “one airway, one disease” has been gaining importance in the last decade. In the upper and lower airways, allergic mechanisms interact with each other. In the initial stage of respiratory allergic inflammation, allergens contact the respiratory epithelium, which produces chemokines and inflammatory factors, which cause allergic reactions by binding to the corresponding receptors and chemotactic various inflammatory cells to reach the epithelium and tissues. It also drives inflammatory cells to activate and produce more inflammatory factors, thus producing a cascade amplification effect. Inflammatory cell aggregation and activation are very complex and interact with each other in a lattice structure. By blocking the action of various chemokines, inflammatory cell aggregation is reduced, and ultimately the symptoms of respiratory allergy are alleviated. Chemokines can serve as cues for coordinated recruitment of immune cells into and out of tissues, as well as directing the spatial organization of immune cells within tissues and cellular interactions. Chemokines are critical in directing immune cell migration and thus have an important role in the direction of respiratory allergy: however, chemokines are also involved in the production and recruitment of immune cells that contribute to respiratory allergy. In this article, linking the upper and lower respiratory tracts. We review the role of the chemokine system in the respiratory immune response and discuss how respiratory disease modulates overall chemokines to shape the type and outcome of the immune response to the treatment of respiratory allergic disease so that we can further deepen our knowledge of chemokines in the direction of respiratory allergy. In the future, we can do drug research and development based on this network structure and explore new research directions. Dove 2022-12-21 /pmc/articles/PMC9790160/ /pubmed/36575714 http://dx.doi.org/10.2147/JAA.S395490 Text en © 2022 Bao and Zhu. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Bao, Youwei
Zhu, Xinhua
Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title_full Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title_fullStr Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title_full_unstemmed Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title_short Role of Chemokines and Inflammatory Cells in Respiratory Allergy
title_sort role of chemokines and inflammatory cells in respiratory allergy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790160/
https://www.ncbi.nlm.nih.gov/pubmed/36575714
http://dx.doi.org/10.2147/JAA.S395490
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