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Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models

Vocacapsaicin is a novel prodrug of trans‐capsaicin (trans‐8‐methyl‐N‐vanillyl‐6‐nonenamide) being developed as a nonopioid, long‐lasting, site‐specific treatment for postsurgical pain management. The objective of these studies was to examine the safety and tolerability of vocacapsaicin in an osteot...

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Detalles Bibliográficos
Autores principales:	Knotts, Tarra, Mease, Kirsten, Sangameswaran, Lakshmi, Felx, Melanie, Kramer, Susan, Donovan, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790453/ https://www.ncbi.nlm.nih.gov/pubmed/35128722 http://dx.doi.org/10.1002/jor.25271

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