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Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog
OBJECTIVE: To report the use of manual therapeutic plasma exchange (TPE) in a dog with severe carprofen toxicity. SUMMARY: A 12‐year‐old neutered female Pembroke Welsh Corgi weighing 20 kg was evaluated after ingesting 223 mg/kg of carprofen. Emesis was attempted with apomorphine at the primary care...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790471/ https://www.ncbi.nlm.nih.gov/pubmed/35527394 http://dx.doi.org/10.1111/vec.13203 |
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author | Buseman, Miranda Blong, April E. Walton, Rebecca A. L. |
author_facet | Buseman, Miranda Blong, April E. Walton, Rebecca A. L. |
author_sort | Buseman, Miranda |
collection | PubMed |
description | OBJECTIVE: To report the use of manual therapeutic plasma exchange (TPE) in a dog with severe carprofen toxicity. SUMMARY: A 12‐year‐old neutered female Pembroke Welsh Corgi weighing 20 kg was evaluated after ingesting 223 mg/kg of carprofen. Emesis was attempted with apomorphine at the primary care veterinarian but was unsuccessful, and a dose of activated charcoal with sorbitol was administered. On presentation to the referral center, approximately 8 hours after ingestion, the dog's physical examination revealed mild abdominal discomfort but was otherwise unremarkable. Treatment consisted of a combination of supportive care including activated charcoal with sorbitol, cholestyramine, IV lipid emulsion, and manual TPE. Blood samples were collected prior to the initiation of manual TPE and at the completion of 12 exchange cycles. Carprofen levels were determined by high‐pressure liquid chromatography. A 57% decrease in carprofen levels was achieved with the combination of activated charcoal, cholestyramine, IV lipid emulsion, and manual TPE. The dog did not develop organ dysfunction secondary to toxicity and was discharged 4 days after ingestion. NEW OR UNIQUE INFORMATION PROVIDED: This report describes the successful decrease of plasma carprofen in a dog with the combination of decontamination techniques and manual TPE. While TPE has been previously reported as a successful therapeutic in dogs with nonsteroidal anti‐inflammatory toxicity, including carprofen, equipment and expertise of this platform is not readily available. Manual TPE is technically simple and can be performed in any hospital with a large blood centrifuge. |
format | Online Article Text |
id | pubmed-9790471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97904712022-12-28 Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog Buseman, Miranda Blong, April E. Walton, Rebecca A. L. J Vet Emerg Crit Care (San Antonio) Case Reports OBJECTIVE: To report the use of manual therapeutic plasma exchange (TPE) in a dog with severe carprofen toxicity. SUMMARY: A 12‐year‐old neutered female Pembroke Welsh Corgi weighing 20 kg was evaluated after ingesting 223 mg/kg of carprofen. Emesis was attempted with apomorphine at the primary care veterinarian but was unsuccessful, and a dose of activated charcoal with sorbitol was administered. On presentation to the referral center, approximately 8 hours after ingestion, the dog's physical examination revealed mild abdominal discomfort but was otherwise unremarkable. Treatment consisted of a combination of supportive care including activated charcoal with sorbitol, cholestyramine, IV lipid emulsion, and manual TPE. Blood samples were collected prior to the initiation of manual TPE and at the completion of 12 exchange cycles. Carprofen levels were determined by high‐pressure liquid chromatography. A 57% decrease in carprofen levels was achieved with the combination of activated charcoal, cholestyramine, IV lipid emulsion, and manual TPE. The dog did not develop organ dysfunction secondary to toxicity and was discharged 4 days after ingestion. NEW OR UNIQUE INFORMATION PROVIDED: This report describes the successful decrease of plasma carprofen in a dog with the combination of decontamination techniques and manual TPE. While TPE has been previously reported as a successful therapeutic in dogs with nonsteroidal anti‐inflammatory toxicity, including carprofen, equipment and expertise of this platform is not readily available. Manual TPE is technically simple and can be performed in any hospital with a large blood centrifuge. John Wiley and Sons Inc. 2022-05-08 2022 /pmc/articles/PMC9790471/ /pubmed/35527394 http://dx.doi.org/10.1111/vec.13203 Text en © Veterinary Emergency and Critical Care Society 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Buseman, Miranda Blong, April E. Walton, Rebecca A. L. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title | Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title_full | Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title_fullStr | Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title_full_unstemmed | Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title_short | Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
title_sort | successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790471/ https://www.ncbi.nlm.nih.gov/pubmed/35527394 http://dx.doi.org/10.1111/vec.13203 |
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