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Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells

The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ(9)‐tetrahydrocannabinol (Δ(9)‐THC) in late 1980s paved the way for investigations on the effects of cannabis‐based therapeutics in brain pathology. Ever since, a wealth of results obtained from stud...

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Autores principales: Bernal‐Chico, Ana, Tepavcevic, Vanja, Manterola, Andrea, Utrilla, Carmen, Matute, Carlos, Mato, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790551/
https://www.ncbi.nlm.nih.gov/pubmed/35353392
http://dx.doi.org/10.1002/glia.24172
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author Bernal‐Chico, Ana
Tepavcevic, Vanja
Manterola, Andrea
Utrilla, Carmen
Matute, Carlos
Mato, Susana
author_facet Bernal‐Chico, Ana
Tepavcevic, Vanja
Manterola, Andrea
Utrilla, Carmen
Matute, Carlos
Mato, Susana
author_sort Bernal‐Chico, Ana
collection PubMed
description The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ(9)‐tetrahydrocannabinol (Δ(9)‐THC) in late 1980s paved the way for investigations on the effects of cannabis‐based therapeutics in brain pathology. Ever since, a wealth of results obtained from studies on human tissue samples and animal models have highlighted a promising therapeutic potential of cannabinoids and endocannabinoids in a variety of neurological disorders. However, clinical success has been limited and major questions concerning endocannabinoid signaling need to be satisfactorily addressed, particularly with regard to their role as modulators of glial cells in neurodegenerative diseases. Indeed, recent studies have brought into the limelight diverse, often unexpected functions of astrocytes, oligodendrocytes, and microglia in brain injury and disease, thus providing scientific basis for targeting glial cells to treat brain disorders. This Review summarizes the current knowledge on the molecular and cellular hallmarks of endocannabinoid signaling in glial cells and its clinical relevance in neurodegenerative and chronic inflammatory disorders.
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spelling pubmed-97905512022-12-28 Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells Bernal‐Chico, Ana Tepavcevic, Vanja Manterola, Andrea Utrilla, Carmen Matute, Carlos Mato, Susana Glia Special Issue Articles The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ(9)‐tetrahydrocannabinol (Δ(9)‐THC) in late 1980s paved the way for investigations on the effects of cannabis‐based therapeutics in brain pathology. Ever since, a wealth of results obtained from studies on human tissue samples and animal models have highlighted a promising therapeutic potential of cannabinoids and endocannabinoids in a variety of neurological disorders. However, clinical success has been limited and major questions concerning endocannabinoid signaling need to be satisfactorily addressed, particularly with regard to their role as modulators of glial cells in neurodegenerative diseases. Indeed, recent studies have brought into the limelight diverse, often unexpected functions of astrocytes, oligodendrocytes, and microglia in brain injury and disease, thus providing scientific basis for targeting glial cells to treat brain disorders. This Review summarizes the current knowledge on the molecular and cellular hallmarks of endocannabinoid signaling in glial cells and its clinical relevance in neurodegenerative and chronic inflammatory disorders. John Wiley & Sons, Inc. 2022-03-30 2023-01 /pmc/articles/PMC9790551/ /pubmed/35353392 http://dx.doi.org/10.1002/glia.24172 Text en © 2022 The Authors. GLIA published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Special Issue Articles
Bernal‐Chico, Ana
Tepavcevic, Vanja
Manterola, Andrea
Utrilla, Carmen
Matute, Carlos
Mato, Susana
Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title_full Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title_fullStr Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title_full_unstemmed Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title_short Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
title_sort endocannabinoid signaling in brain diseases: emerging relevance of glial cells
topic Special Issue Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790551/
https://www.ncbi.nlm.nih.gov/pubmed/35353392
http://dx.doi.org/10.1002/glia.24172
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