Mucosal microbiotas and their role in stem cell transplantation

Mucosal microbiotas and their role in stem cell transplantation. Patients with hematological disorders such as leukemia often undergo allogeneic hematopoietic stem cell transplantation, and thereby receive stem cells from a donor for curation of disease. This procedure also involves immunosuppressiv...

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Autores principales: Ingham, Anna Cäcilia, Pamp, Sünje Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790582/
https://www.ncbi.nlm.nih.gov/pubmed/35060190
http://dx.doi.org/10.1111/apm.13208
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author Ingham, Anna Cäcilia
Pamp, Sünje Johanna
author_facet Ingham, Anna Cäcilia
Pamp, Sünje Johanna
author_sort Ingham, Anna Cäcilia
collection PubMed
description Mucosal microbiotas and their role in stem cell transplantation. Patients with hematological disorders such as leukemia often undergo allogeneic hematopoietic stem cell transplantation, and thereby receive stem cells from a donor for curation of disease. This procedure also involves immunosuppressive and antimicrobial treatments that disturb the important interactions between the microbiota and the immune system, especially at mucosal sites. After transplantation, bacterial diversity decreases together with a depletion of Clostridia, and shifts toward predominance of Proteobacteria. Infectious and inflammatory complications, such as graft‐versus‐host disease, also interfere with patient recovery. This review collects and contextualizes current knowledge of the role of mucosal microbiotas at different body sites in stem cell transplantation, proposes underlying mechanisms, and discusses potential clinical value of bacterial markers for improved treatment strategies.
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spelling pubmed-97905822022-12-28 Mucosal microbiotas and their role in stem cell transplantation Ingham, Anna Cäcilia Pamp, Sünje Johanna APMIS Review Articles Mucosal microbiotas and their role in stem cell transplantation. Patients with hematological disorders such as leukemia often undergo allogeneic hematopoietic stem cell transplantation, and thereby receive stem cells from a donor for curation of disease. This procedure also involves immunosuppressive and antimicrobial treatments that disturb the important interactions between the microbiota and the immune system, especially at mucosal sites. After transplantation, bacterial diversity decreases together with a depletion of Clostridia, and shifts toward predominance of Proteobacteria. Infectious and inflammatory complications, such as graft‐versus‐host disease, also interfere with patient recovery. This review collects and contextualizes current knowledge of the role of mucosal microbiotas at different body sites in stem cell transplantation, proposes underlying mechanisms, and discusses potential clinical value of bacterial markers for improved treatment strategies. John Wiley and Sons Inc. 2022-02-09 2022-12 /pmc/articles/PMC9790582/ /pubmed/35060190 http://dx.doi.org/10.1111/apm.13208 Text en © 2022 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Ingham, Anna Cäcilia
Pamp, Sünje Johanna
Mucosal microbiotas and their role in stem cell transplantation
title Mucosal microbiotas and their role in stem cell transplantation
title_full Mucosal microbiotas and their role in stem cell transplantation
title_fullStr Mucosal microbiotas and their role in stem cell transplantation
title_full_unstemmed Mucosal microbiotas and their role in stem cell transplantation
title_short Mucosal microbiotas and their role in stem cell transplantation
title_sort mucosal microbiotas and their role in stem cell transplantation
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790582/
https://www.ncbi.nlm.nih.gov/pubmed/35060190
http://dx.doi.org/10.1111/apm.13208
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