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Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam
Colistin is a critically important antimicrobial for human medicine, and colistin‐resistant Escherichia coli are commonly found in poultry and poultry products in Southeast Asia. Here, we aim at disentangling the within‐farm and outside‐farm drivers of colistin resistance in small‐scale chicken farm...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790599/ https://www.ncbi.nlm.nih.gov/pubmed/35419995 http://dx.doi.org/10.1111/tbed.14558 |
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author | Bastard, Jonathan Nhung, Nguyen Thi Hien, Vo Be Kiet, Bach Tuan Temime, Laura Opatowski, Lulla Carrique‐Mas, Juan Choisy, Marc |
author_facet | Bastard, Jonathan Nhung, Nguyen Thi Hien, Vo Be Kiet, Bach Tuan Temime, Laura Opatowski, Lulla Carrique‐Mas, Juan Choisy, Marc |
author_sort | Bastard, Jonathan |
collection | PubMed |
description | Colistin is a critically important antimicrobial for human medicine, and colistin‐resistant Escherichia coli are commonly found in poultry and poultry products in Southeast Asia. Here, we aim at disentangling the within‐farm and outside‐farm drivers of colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam. Nineteen Vietnamese chicken farms were followed up along a whole production cycle, during which weekly antimicrobial use data were recorded. At the beginning, middle and end of each production cycle, commensal E. coli samples from birds were collected, pooled and tested for colistin resistance. Twelve models were fitted to the data using an expectation–maximization algorithm and compared. We further tested the spatial clustering of the occurrence of resistance importations from external sources using the local Moran's I statistic. In the best model, colistin resistance in E. coli from chickens was found to be mostly affected by importations of resistance, and, to a lesser extent, by the use of antimicrobials in the last 1.73 weeks [0.00; 2.90], but not by the use of antimicrobials in day‐olds, nor their colistin resistance carriage from hatchery. The occurrence of external source importations proved to be sometimes spatially clustered, suggesting a role of local environmental sources of colistin resistance. |
format | Online Article Text |
id | pubmed-9790599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97905992022-12-28 Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam Bastard, Jonathan Nhung, Nguyen Thi Hien, Vo Be Kiet, Bach Tuan Temime, Laura Opatowski, Lulla Carrique‐Mas, Juan Choisy, Marc Transbound Emerg Dis Original Articles Colistin is a critically important antimicrobial for human medicine, and colistin‐resistant Escherichia coli are commonly found in poultry and poultry products in Southeast Asia. Here, we aim at disentangling the within‐farm and outside‐farm drivers of colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam. Nineteen Vietnamese chicken farms were followed up along a whole production cycle, during which weekly antimicrobial use data were recorded. At the beginning, middle and end of each production cycle, commensal E. coli samples from birds were collected, pooled and tested for colistin resistance. Twelve models were fitted to the data using an expectation–maximization algorithm and compared. We further tested the spatial clustering of the occurrence of resistance importations from external sources using the local Moran's I statistic. In the best model, colistin resistance in E. coli from chickens was found to be mostly affected by importations of resistance, and, to a lesser extent, by the use of antimicrobials in the last 1.73 weeks [0.00; 2.90], but not by the use of antimicrobials in day‐olds, nor their colistin resistance carriage from hatchery. The occurrence of external source importations proved to be sometimes spatially clustered, suggesting a role of local environmental sources of colistin resistance. John Wiley and Sons Inc. 2022-05-05 2022-09 /pmc/articles/PMC9790599/ /pubmed/35419995 http://dx.doi.org/10.1111/tbed.14558 Text en © 2022 The Authors. Transboundary and Emerging Diseases published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Bastard, Jonathan Nhung, Nguyen Thi Hien, Vo Be Kiet, Bach Tuan Temime, Laura Opatowski, Lulla Carrique‐Mas, Juan Choisy, Marc Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title | Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title_full | Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title_fullStr | Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title_full_unstemmed | Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title_short | Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small‐scale chicken farms of the Mekong delta of Vietnam |
title_sort | modelling the impact of antimicrobial use and external introductions on commensal e. coli colistin resistance in small‐scale chicken farms of the mekong delta of vietnam |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790599/ https://www.ncbi.nlm.nih.gov/pubmed/35419995 http://dx.doi.org/10.1111/tbed.14558 |
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