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Endocannabinoid signaling in glioma

High‐grade gliomas constitute the most frequent and aggressive form of primary brain cancer in adults. These tumors express cannabinoid CB(1) and CB(2) receptors, as well as other elements of the endocannabinoid system. Accruing preclinical evidence supports that pharmacological activation of cannab...

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Detalles Bibliográficos
Autores principales: Costas‐Insua, Carlos, Guzmán, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790654/
https://www.ncbi.nlm.nih.gov/pubmed/35322459
http://dx.doi.org/10.1002/glia.24173
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author Costas‐Insua, Carlos
Guzmán, Manuel
author_facet Costas‐Insua, Carlos
Guzmán, Manuel
author_sort Costas‐Insua, Carlos
collection PubMed
description High‐grade gliomas constitute the most frequent and aggressive form of primary brain cancer in adults. These tumors express cannabinoid CB(1) and CB(2) receptors, as well as other elements of the endocannabinoid system. Accruing preclinical evidence supports that pharmacological activation of cannabinoid receptors located on glioma cells exerts overt anti‐tumoral effects by modulating key intracellular signaling pathways. The mechanism of this cannabinoid receptor‐evoked anti‐tumoral activity in experimental models of glioma is intricate and may involve an inhibition not only of cancer cell survival/proliferation, but also of invasiveness, angiogenesis, and the stem cell‐like properties of cancer cells, thereby affecting the complex tumor microenvironment. However, the precise biological role of the endocannabinoid system in the generation and progression of glioma seems very context‐dependent and remains largely unknown. Increasing our basic knowledge on how (endo)cannabinoids act on glioma cells could help to optimize experimental cannabinoid‐based anti‐tumoral therapies, as well as the preliminary clinical testing that is currently underway.
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spelling pubmed-97906542022-12-28 Endocannabinoid signaling in glioma Costas‐Insua, Carlos Guzmán, Manuel Glia Special Issue Articles High‐grade gliomas constitute the most frequent and aggressive form of primary brain cancer in adults. These tumors express cannabinoid CB(1) and CB(2) receptors, as well as other elements of the endocannabinoid system. Accruing preclinical evidence supports that pharmacological activation of cannabinoid receptors located on glioma cells exerts overt anti‐tumoral effects by modulating key intracellular signaling pathways. The mechanism of this cannabinoid receptor‐evoked anti‐tumoral activity in experimental models of glioma is intricate and may involve an inhibition not only of cancer cell survival/proliferation, but also of invasiveness, angiogenesis, and the stem cell‐like properties of cancer cells, thereby affecting the complex tumor microenvironment. However, the precise biological role of the endocannabinoid system in the generation and progression of glioma seems very context‐dependent and remains largely unknown. Increasing our basic knowledge on how (endo)cannabinoids act on glioma cells could help to optimize experimental cannabinoid‐based anti‐tumoral therapies, as well as the preliminary clinical testing that is currently underway. John Wiley & Sons, Inc. 2022-03-24 2023-01 /pmc/articles/PMC9790654/ /pubmed/35322459 http://dx.doi.org/10.1002/glia.24173 Text en © 2022 The Authors. GLIA published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Articles
Costas‐Insua, Carlos
Guzmán, Manuel
Endocannabinoid signaling in glioma
title Endocannabinoid signaling in glioma
title_full Endocannabinoid signaling in glioma
title_fullStr Endocannabinoid signaling in glioma
title_full_unstemmed Endocannabinoid signaling in glioma
title_short Endocannabinoid signaling in glioma
title_sort endocannabinoid signaling in glioma
topic Special Issue Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790654/
https://www.ncbi.nlm.nih.gov/pubmed/35322459
http://dx.doi.org/10.1002/glia.24173
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