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Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues

BACKGROUND: The developmental toxicity potential (dTP) concentration from the devTOX quickPredict (devTOX( qP )) assay, a metabolomics‐based human induced pluripotent stem cell assay, predicts a chemical's developmental toxicity potency. Here, in vitro to in vivo extrapolation (IVIVE) approache...

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Detalles Bibliográficos
Autores principales:	Chang, Xiaoqing, Palmer, Jessica, Lumen, Annie, Lee, Un Jung, Ceger, Patricia, Mansouri, Kamel, Sprankle, Catherine, Donley, Elizabeth, Bell, Shannon, Knudsen, Thomas B., Wambaugh, John, Cook, Bethany, Allen, David, Kleinstreuer, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790683/ https://www.ncbi.nlm.nih.gov/pubmed/35532929 http://dx.doi.org/10.1002/bdr2.2019

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