Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers

We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our previous preclinical study that demonstrated the sign...

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Autores principales: Nakamura, Hajime, Takada, Kohichi, Emori, Makoto, Hayasaka, Naotaka, Sugita, Shintaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790770/
https://www.ncbi.nlm.nih.gov/pubmed/35527027
http://dx.doi.org/10.2169/internalmedicine.9423-22
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author Nakamura, Hajime
Takada, Kohichi
Emori, Makoto
Hayasaka, Naotaka
Sugita, Shintaro
author_facet Nakamura, Hajime
Takada, Kohichi
Emori, Makoto
Hayasaka, Naotaka
Sugita, Shintaro
author_sort Nakamura, Hajime
collection PubMed
description We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our previous preclinical study that demonstrated the significance of p-AKT signaling for eribulin resistance in multiple subtypes of soft tissue sarcoma (STS) cells. This case highlights the potential benefits of eribulin as well as the mechanism underlying resistance to eribulin in patients with unresectable or metastatic STS, especially liposarcoma.
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spelling pubmed-97907702023-01-05 Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers Nakamura, Hajime Takada, Kohichi Emori, Makoto Hayasaka, Naotaka Sugita, Shintaro Intern Med Case Report We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our previous preclinical study that demonstrated the significance of p-AKT signaling for eribulin resistance in multiple subtypes of soft tissue sarcoma (STS) cells. This case highlights the potential benefits of eribulin as well as the mechanism underlying resistance to eribulin in patients with unresectable or metastatic STS, especially liposarcoma. The Japanese Society of Internal Medicine 2022-05-07 2022-12-01 /pmc/articles/PMC9790770/ /pubmed/35527027 http://dx.doi.org/10.2169/internalmedicine.9423-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakamura, Hajime
Takada, Kohichi
Emori, Makoto
Hayasaka, Naotaka
Sugita, Shintaro
Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title_full Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title_fullStr Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title_full_unstemmed Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title_short Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers
title_sort complete response to eribulin in a patient with unresectable liposarcoma: a case report and implications of new biomarkers
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790770/
https://www.ncbi.nlm.nih.gov/pubmed/35527027
http://dx.doi.org/10.2169/internalmedicine.9423-22
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