Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin

A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branch...

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Detalles Bibliográficos
Autores principales: Ishimoto, Hiroshi, Sakamoto, Noriho, Hara, Atsuko, Kido, Takashi, Yamaguchi, Hiroyuki, Yamamoto, Kazuko, Obase, Yasushi, Ishimatsu, Yuji, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790779/
https://www.ncbi.nlm.nih.gov/pubmed/35466169
http://dx.doi.org/10.2169/internalmedicine.9304-21
Descripción
Sumario:A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branching shadows on chest HRCT suggestive of diffuse panbronchiolitis, he exhibited sinusitis and had the human leukocyte antigen (HLA)-B54 antigen. With long-term macrolide therapy, the cough and sputum production markedly improved, wall thickening of the honeycomb lung on chest HRCT decreased, and the forced vital capacity increased. Confirming the presence of HLA-B54 antigen may help determine the indication for long-term macrolide therapy in interstitial pneumonia patients.

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