Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin

A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branch...

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Autores principales: Ishimoto, Hiroshi, Sakamoto, Noriho, Hara, Atsuko, Kido, Takashi, Yamaguchi, Hiroyuki, Yamamoto, Kazuko, Obase, Yasushi, Ishimatsu, Yuji, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790779/
https://www.ncbi.nlm.nih.gov/pubmed/35466169
http://dx.doi.org/10.2169/internalmedicine.9304-21
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author Ishimoto, Hiroshi
Sakamoto, Noriho
Hara, Atsuko
Kido, Takashi
Yamaguchi, Hiroyuki
Yamamoto, Kazuko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
author_facet Ishimoto, Hiroshi
Sakamoto, Noriho
Hara, Atsuko
Kido, Takashi
Yamaguchi, Hiroyuki
Yamamoto, Kazuko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
author_sort Ishimoto, Hiroshi
collection PubMed
description A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branching shadows on chest HRCT suggestive of diffuse panbronchiolitis, he exhibited sinusitis and had the human leukocyte antigen (HLA)-B54 antigen. With long-term macrolide therapy, the cough and sputum production markedly improved, wall thickening of the honeycomb lung on chest HRCT decreased, and the forced vital capacity increased. Confirming the presence of HLA-B54 antigen may help determine the indication for long-term macrolide therapy in interstitial pneumonia patients.
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spelling pubmed-97907792023-01-05 Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin Ishimoto, Hiroshi Sakamoto, Noriho Hara, Atsuko Kido, Takashi Yamaguchi, Hiroyuki Yamamoto, Kazuko Obase, Yasushi Ishimatsu, Yuji Mukae, Hiroshi Intern Med Case Report A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branching shadows on chest HRCT suggestive of diffuse panbronchiolitis, he exhibited sinusitis and had the human leukocyte antigen (HLA)-B54 antigen. With long-term macrolide therapy, the cough and sputum production markedly improved, wall thickening of the honeycomb lung on chest HRCT decreased, and the forced vital capacity increased. Confirming the presence of HLA-B54 antigen may help determine the indication for long-term macrolide therapy in interstitial pneumonia patients. The Japanese Society of Internal Medicine 2022-04-23 2022-12-01 /pmc/articles/PMC9790779/ /pubmed/35466169 http://dx.doi.org/10.2169/internalmedicine.9304-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishimoto, Hiroshi
Sakamoto, Noriho
Hara, Atsuko
Kido, Takashi
Yamaguchi, Hiroyuki
Yamamoto, Kazuko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title_full Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title_fullStr Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title_full_unstemmed Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title_short Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin
title_sort interstitial pneumonia with hla-b54 antigen that responded well to erythromycin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790779/
https://www.ncbi.nlm.nih.gov/pubmed/35466169
http://dx.doi.org/10.2169/internalmedicine.9304-21
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