FLAMES with Elevated Myelin Basic Protein Followed by Myelitis

The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased sign...

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Detalles Bibliográficos
Autores principales: Hokama, Hiroyuki, Sakamoto, Yuki, Hayashi, Toshiyuki, Hatake, Seira, Takahashi, Mizuho, Kodera, Hiroto, Kutsuna, Akihito, Nito, Chikako, Nakane, Shunya, Nagayama, Hiroshi, Takahashi, Toshiyuki, Kimura, Kazumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790785/
https://www.ncbi.nlm.nih.gov/pubmed/35527028
http://dx.doi.org/10.2169/internalmedicine.9439-22
Descripción
Sumario:The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased signal intensity and swelling of the right frontal cortex. His symptoms and imaging abnormalities were improved after intravenous methylprednisolone therapy. MOG antibody was detected both in serum and cerebrospinal fluid (CSF). Therefore, the patient was diagnosed with FLAMES. Myelin basic protein (MBP) was elevated in CSF. The high MBP value in the CSF in the present case suggested that demyelination as well as inflammation can occur in some FLAMES patients.

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