FLAMES with Elevated Myelin Basic Protein Followed by Myelitis

The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased sign...

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Detalles Bibliográficos
Autores principales: Hokama, Hiroyuki, Sakamoto, Yuki, Hayashi, Toshiyuki, Hatake, Seira, Takahashi, Mizuho, Kodera, Hiroto, Kutsuna, Akihito, Nito, Chikako, Nakane, Shunya, Nagayama, Hiroshi, Takahashi, Toshiyuki, Kimura, Kazumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790785/
https://www.ncbi.nlm.nih.gov/pubmed/35527028
http://dx.doi.org/10.2169/internalmedicine.9439-22
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author Hokama, Hiroyuki
Sakamoto, Yuki
Hayashi, Toshiyuki
Hatake, Seira
Takahashi, Mizuho
Kodera, Hiroto
Kutsuna, Akihito
Nito, Chikako
Nakane, Shunya
Nagayama, Hiroshi
Takahashi, Toshiyuki
Kimura, Kazumi
author_facet Hokama, Hiroyuki
Sakamoto, Yuki
Hayashi, Toshiyuki
Hatake, Seira
Takahashi, Mizuho
Kodera, Hiroto
Kutsuna, Akihito
Nito, Chikako
Nakane, Shunya
Nagayama, Hiroshi
Takahashi, Toshiyuki
Kimura, Kazumi
author_sort Hokama, Hiroyuki
collection PubMed
description The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased signal intensity and swelling of the right frontal cortex. His symptoms and imaging abnormalities were improved after intravenous methylprednisolone therapy. MOG antibody was detected both in serum and cerebrospinal fluid (CSF). Therefore, the patient was diagnosed with FLAMES. Myelin basic protein (MBP) was elevated in CSF. The high MBP value in the CSF in the present case suggested that demyelination as well as inflammation can occur in some FLAMES patients.
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spelling pubmed-97907852023-01-05 FLAMES with Elevated Myelin Basic Protein Followed by Myelitis Hokama, Hiroyuki Sakamoto, Yuki Hayashi, Toshiyuki Hatake, Seira Takahashi, Mizuho Kodera, Hiroto Kutsuna, Akihito Nito, Chikako Nakane, Shunya Nagayama, Hiroshi Takahashi, Toshiyuki Kimura, Kazumi Intern Med Case Report The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased signal intensity and swelling of the right frontal cortex. His symptoms and imaging abnormalities were improved after intravenous methylprednisolone therapy. MOG antibody was detected both in serum and cerebrospinal fluid (CSF). Therefore, the patient was diagnosed with FLAMES. Myelin basic protein (MBP) was elevated in CSF. The high MBP value in the CSF in the present case suggested that demyelination as well as inflammation can occur in some FLAMES patients. The Japanese Society of Internal Medicine 2022-05-07 2022-12-01 /pmc/articles/PMC9790785/ /pubmed/35527028 http://dx.doi.org/10.2169/internalmedicine.9439-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hokama, Hiroyuki
Sakamoto, Yuki
Hayashi, Toshiyuki
Hatake, Seira
Takahashi, Mizuho
Kodera, Hiroto
Kutsuna, Akihito
Nito, Chikako
Nakane, Shunya
Nagayama, Hiroshi
Takahashi, Toshiyuki
Kimura, Kazumi
FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title_full FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title_fullStr FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title_full_unstemmed FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title_short FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
title_sort flames with elevated myelin basic protein followed by myelitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790785/
https://www.ncbi.nlm.nih.gov/pubmed/35527028
http://dx.doi.org/10.2169/internalmedicine.9439-22
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