Seronegative Full-house Nephropathy with Crohn's Disease

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular “full-house” immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can als...

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Detalles Bibliográficos
Autores principales: Uedono, Hideki, Tsuda, Akihiro, Ueno, Noriko, Natsuki, Yuka, Nakaya, Rino, Nishide, Kozo, Machiba, Yuri, Fujimoto, Kenta, Nakatani, Shinya, Mori, Katsuhito, Emoto, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790786/
https://www.ncbi.nlm.nih.gov/pubmed/35527024
http://dx.doi.org/10.2169/internalmedicine.8820-21
Descripción
Sumario:Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular “full-house” immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a “full-house” immunofluorescence pattern. We recently encountered a patient with full-house nephropathy (FHN) during adalimumab administration for Crohn's disease. IgA nephropathy or idiopathic FHN was diagnosed, and treatment with steroids was started, after which there was improvement in proteinuria. The prognosis of FHN has been reported to be poor; therefore, aggressive treatment is required for such patients.

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