Bing-Neel Syndrome Successfully Treated with Tirabrutinib

Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marro...

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Detalles Bibliográficos
Autores principales: Oyama, Takashi, Taoka, Kazuki, Chiba, Akira, Matsuda, Kensuke, Maki, Hiroaki, Masamoto, Yosuke, Kurokawa, Mineo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790791/
https://www.ncbi.nlm.nih.gov/pubmed/35569989
http://dx.doi.org/10.2169/internalmedicine.9545-22
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author Oyama, Takashi
Taoka, Kazuki
Chiba, Akira
Matsuda, Kensuke
Maki, Hiroaki
Masamoto, Yosuke
Kurokawa, Mineo
author_facet Oyama, Takashi
Taoka, Kazuki
Chiba, Akira
Matsuda, Kensuke
Maki, Hiroaki
Masamoto, Yosuke
Kurokawa, Mineo
author_sort Oyama, Takashi
collection PubMed
description Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marrow examination showed lymphoplasmacytic cells infiltration. Contrast-enhanced magnetic resonance imaging suggested enhancing lesions in the cauda equina roots. He was diagnosed with BNS and started on treatment with tirabrutinib 480 mg daily. Within three months, he showed clinical and radiologic improvement. Tirabrutinib may have utility as an effective treatment for BNS.
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spelling pubmed-97907912023-01-05 Bing-Neel Syndrome Successfully Treated with Tirabrutinib Oyama, Takashi Taoka, Kazuki Chiba, Akira Matsuda, Kensuke Maki, Hiroaki Masamoto, Yosuke Kurokawa, Mineo Intern Med Case Report Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marrow examination showed lymphoplasmacytic cells infiltration. Contrast-enhanced magnetic resonance imaging suggested enhancing lesions in the cauda equina roots. He was diagnosed with BNS and started on treatment with tirabrutinib 480 mg daily. Within three months, he showed clinical and radiologic improvement. Tirabrutinib may have utility as an effective treatment for BNS. The Japanese Society of Internal Medicine 2022-05-14 2022-12-01 /pmc/articles/PMC9790791/ /pubmed/35569989 http://dx.doi.org/10.2169/internalmedicine.9545-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Oyama, Takashi
Taoka, Kazuki
Chiba, Akira
Matsuda, Kensuke
Maki, Hiroaki
Masamoto, Yosuke
Kurokawa, Mineo
Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title_full Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title_fullStr Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title_full_unstemmed Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title_short Bing-Neel Syndrome Successfully Treated with Tirabrutinib
title_sort bing-neel syndrome successfully treated with tirabrutinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790791/
https://www.ncbi.nlm.nih.gov/pubmed/35569989
http://dx.doi.org/10.2169/internalmedicine.9545-22
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