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Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790798/ https://www.ncbi.nlm.nih.gov/pubmed/36104199 http://dx.doi.org/10.2169/internalmedicine.0404-22 |
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author | Tanemoto, Masanobu Oda, Ryosuke Toyama, Yuichiro Shizukawa, Hirohiko Yokokawa, Kazuki Saito, Taro Suzuki, Syuuichirou Matsumura, Akihiro Hisahara, Shin |
author_facet | Tanemoto, Masanobu Oda, Ryosuke Toyama, Yuichiro Shizukawa, Hirohiko Yokokawa, Kazuki Saito, Taro Suzuki, Syuuichirou Matsumura, Akihiro Hisahara, Shin |
author_sort | Tanemoto, Masanobu |
collection | PubMed |
description | A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably. |
format | Online Article Text |
id | pubmed-9790798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-97907982023-01-05 Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination Tanemoto, Masanobu Oda, Ryosuke Toyama, Yuichiro Shizukawa, Hirohiko Yokokawa, Kazuki Saito, Taro Suzuki, Syuuichirou Matsumura, Akihiro Hisahara, Shin Intern Med Case Report A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably. The Japanese Society of Internal Medicine 2022-09-13 2022-12-01 /pmc/articles/PMC9790798/ /pubmed/36104199 http://dx.doi.org/10.2169/internalmedicine.0404-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Tanemoto, Masanobu Oda, Ryosuke Toyama, Yuichiro Shizukawa, Hirohiko Yokokawa, Kazuki Saito, Taro Suzuki, Syuuichirou Matsumura, Akihiro Hisahara, Shin Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title | Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title_full | Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title_fullStr | Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title_full_unstemmed | Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title_short | Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination |
title_sort | anti-signal recognition particle antibody-positive immune-mediated myopathy after mrna-1273 sars-cov-2 vaccination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790798/ https://www.ncbi.nlm.nih.gov/pubmed/36104199 http://dx.doi.org/10.2169/internalmedicine.0404-22 |
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