Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, an...

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Autores principales: Tanemoto, Masanobu, Oda, Ryosuke, Toyama, Yuichiro, Shizukawa, Hirohiko, Yokokawa, Kazuki, Saito, Taro, Suzuki, Syuuichirou, Matsumura, Akihiro, Hisahara, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790798/
https://www.ncbi.nlm.nih.gov/pubmed/36104199
http://dx.doi.org/10.2169/internalmedicine.0404-22
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author Tanemoto, Masanobu
Oda, Ryosuke
Toyama, Yuichiro
Shizukawa, Hirohiko
Yokokawa, Kazuki
Saito, Taro
Suzuki, Syuuichirou
Matsumura, Akihiro
Hisahara, Shin
author_facet Tanemoto, Masanobu
Oda, Ryosuke
Toyama, Yuichiro
Shizukawa, Hirohiko
Yokokawa, Kazuki
Saito, Taro
Suzuki, Syuuichirou
Matsumura, Akihiro
Hisahara, Shin
author_sort Tanemoto, Masanobu
collection PubMed
description A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
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spelling pubmed-97907982023-01-05 Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination Tanemoto, Masanobu Oda, Ryosuke Toyama, Yuichiro Shizukawa, Hirohiko Yokokawa, Kazuki Saito, Taro Suzuki, Syuuichirou Matsumura, Akihiro Hisahara, Shin Intern Med Case Report A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably. The Japanese Society of Internal Medicine 2022-09-13 2022-12-01 /pmc/articles/PMC9790798/ /pubmed/36104199 http://dx.doi.org/10.2169/internalmedicine.0404-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tanemoto, Masanobu
Oda, Ryosuke
Toyama, Yuichiro
Shizukawa, Hirohiko
Yokokawa, Kazuki
Saito, Taro
Suzuki, Syuuichirou
Matsumura, Akihiro
Hisahara, Shin
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title_full Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title_fullStr Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title_full_unstemmed Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title_short Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
title_sort anti-signal recognition particle antibody-positive immune-mediated myopathy after mrna-1273 sars-cov-2 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790798/
https://www.ncbi.nlm.nih.gov/pubmed/36104199
http://dx.doi.org/10.2169/internalmedicine.0404-22
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