Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syn...

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Autores principales: De Smet, Maarten A. J., Bogaert, Simon, Schauwvlieghe, Alexander, Dendooven, Amélie, Depuydt, Pieter, Druwé, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790895/
https://www.ncbi.nlm.nih.gov/pubmed/36579154
http://dx.doi.org/10.3389/fmed.2022.1096900
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author De Smet, Maarten A. J.
Bogaert, Simon
Schauwvlieghe, Alexander
Dendooven, Amélie
Depuydt, Pieter
Druwé, Patrick
author_facet De Smet, Maarten A. J.
Bogaert, Simon
Schauwvlieghe, Alexander
Dendooven, Amélie
Depuydt, Pieter
Druwé, Patrick
author_sort De Smet, Maarten A. J.
collection PubMed
description Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syndrome, hypertriglyceridemia, hemophagocytosis, very high ferritin and significantly elevated sCD25. The findings were compatible with hemophagocytic lymphohistiocytosis based on the HLH-2004 criteria. Serological testing indentified Puumala virus as the causal pathogen. The patient was successfully treated with pulse corticosteroids, intravenous immunoglobins and supportive therapy.
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spelling pubmed-97908952022-12-27 Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis De Smet, Maarten A. J. Bogaert, Simon Schauwvlieghe, Alexander Dendooven, Amélie Depuydt, Pieter Druwé, Patrick Front Med (Lausanne) Medicine Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syndrome, hypertriglyceridemia, hemophagocytosis, very high ferritin and significantly elevated sCD25. The findings were compatible with hemophagocytic lymphohistiocytosis based on the HLH-2004 criteria. Serological testing indentified Puumala virus as the causal pathogen. The patient was successfully treated with pulse corticosteroids, intravenous immunoglobins and supportive therapy. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9790895/ /pubmed/36579154 http://dx.doi.org/10.3389/fmed.2022.1096900 Text en Copyright © 2022 De Smet, Bogaert, Schauwvlieghe, Dendooven, Depuydt and Druwé. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
De Smet, Maarten A. J.
Bogaert, Simon
Schauwvlieghe, Alexander
Dendooven, Amélie
Depuydt, Pieter
Druwé, Patrick
Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title_full Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title_fullStr Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title_full_unstemmed Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title_short Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
title_sort case report: hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790895/
https://www.ncbi.nlm.nih.gov/pubmed/36579154
http://dx.doi.org/10.3389/fmed.2022.1096900
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