Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development

The Raf/MEK/ERK signaling pathway plays a key role in regulating cellular proliferation, differentiation, apoptosis, cytokine production, and immune responses. However, it is also involved in diseases such as cancer, and numerous viruses rely on an active Raf/MEK/ERK pathway for propagation. This pa...

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Detalles Bibliográficos
Autores principales: Schüssele, Lara M., Koch-Heier, Julia, Volk, Julian, Löffler, Markus W., Hoffmann, Katharina, Bruyns, Regina M., Planz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790982/
https://www.ncbi.nlm.nih.gov/pubmed/36578787
http://dx.doi.org/10.3389/fcell.2022.1063692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790982/
https://www.ncbi.nlm.nih.gov/pubmed/36578787
http://dx.doi.org/10.3389/fcell.2022.1063692

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