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Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study

OBJECTIVES: To assess the impact of conventional transcatheter heart valve (THV) commissural alignment techniques on THV/coronary overlap and coronary access (CA) after transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BAV). BACKGROUND: Specific Evolut Pro/Pro + and Acurate Neo...

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Autores principales: Tarantini, Giuseppe, Fabris, Tommaso, Nai Fovino, Luca, Cardaioli, Francesco, Pergola, Valeria, Montonati, Carolina, Rodinò, Giulio, Cabrelle, Giulio, Massussi, Mauro, Scotti, Andrea, Zuccarelli, Vittorio, Sciarretta, Tommaso, Masiero, Giulia, Gregori, Dario, Napodano, Massimo, Fraccaro, Chiara, Continisio, Saverio, Iliceto, Sabino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790995/
https://www.ncbi.nlm.nih.gov/pubmed/36578836
http://dx.doi.org/10.3389/fcvm.2022.1056496
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author Tarantini, Giuseppe
Fabris, Tommaso
Nai Fovino, Luca
Cardaioli, Francesco
Pergola, Valeria
Montonati, Carolina
Rodinò, Giulio
Cabrelle, Giulio
Massussi, Mauro
Scotti, Andrea
Zuccarelli, Vittorio
Sciarretta, Tommaso
Masiero, Giulia
Gregori, Dario
Napodano, Massimo
Fraccaro, Chiara
Continisio, Saverio
Iliceto, Sabino
author_facet Tarantini, Giuseppe
Fabris, Tommaso
Nai Fovino, Luca
Cardaioli, Francesco
Pergola, Valeria
Montonati, Carolina
Rodinò, Giulio
Cabrelle, Giulio
Massussi, Mauro
Scotti, Andrea
Zuccarelli, Vittorio
Sciarretta, Tommaso
Masiero, Giulia
Gregori, Dario
Napodano, Massimo
Fraccaro, Chiara
Continisio, Saverio
Iliceto, Sabino
author_sort Tarantini, Giuseppe
collection PubMed
description OBJECTIVES: To assess the impact of conventional transcatheter heart valve (THV) commissural alignment techniques on THV/coronary overlap and coronary access (CA) after transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BAV). BACKGROUND: Specific Evolut Pro/Pro + and Acurate Neo2 THV orientations are associated with reduced neo-commissural overlap with coronary ostia in tricuspid aortic anatomy. Whether standard orientation techniques are effective also in the setting of BAV anatomy has not been studied. METHODS: The DA VINCI (Definition of trAnscatheter aortic Valve orIeNtation in biCuspId aortic valve) pilot study is a prospective registry enrolling consecutive patients with severe BAV stenosis undergoing TAVR with last generation supra-annular tall-frame THVs implanted with a cusp overlap view-based commissural alignment. Patients underwent pre- and post-TAVR computed tomography (CT) and coronary angiography. The study endpoint was the rate of favorable THV/coronary overlap, defined as an angle > 40° between the THV commissural post and coronary ostia. Other endpoints were the rates of successful THV alignment with respect to the raphe and of selective CA after TAVR. Moreover, different virtual THV alignment models were tested to identify which one would produce the lower degree of THV/coronary overlap. RESULTS: Thirty-four patients with type 1 BAV with right-left raphe undergoing TAVR (23 with Evolut Pro/Pro + and 11 with Acurate Neo2) were included. At pre-TAVR CT, moderate/severe cusp asymmetry was found in 50% of patients, severe coronary ostia eccentricity was observed in 47.1% for the RCA vs. 8.8% for the LCA (P < 0.007). Correct TVH orientation was achieved in 29 cases. At post-TAVR CT, optimal THV alignment/mild misalignment to the raphe was observed in 86.2%, but a moderate/severe overlap with the coronaries was seen in 13.7% for the RCA and 44.8% for the LCA (P = 0.019). After TAVR, selective RCA cannulation was possible in 82.8% vs. 75.9% for the LCA (P = 0.74), while combined selective CA of both coronaries was possible in less than two-thirds of the patients. Virtual THV alignment in the coronary ostia overlap view assuming a hypothetical circular THV expansion would produce an optimal THV/coronary overlap in almost 90% of cases. CONCLUSION: Given cusp asymmetry and coronary ostia eccentricity of BAV combined with potential THV asymmetrical expansion, conventional commissural alignment techniques are associated with higher rates of THV misalignment and of moderate/severe neo-commissure overlap with the coronary ostia as compared to tricuspid aortic stenosis, resulting in lower rates of selective CA after TAVR. A modified THV orientation technique based on the coronary ostia overlap view might be preferable in BAV patients.
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spelling pubmed-97909952022-12-27 Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study Tarantini, Giuseppe Fabris, Tommaso Nai Fovino, Luca Cardaioli, Francesco Pergola, Valeria Montonati, Carolina Rodinò, Giulio Cabrelle, Giulio Massussi, Mauro Scotti, Andrea Zuccarelli, Vittorio Sciarretta, Tommaso Masiero, Giulia Gregori, Dario Napodano, Massimo Fraccaro, Chiara Continisio, Saverio Iliceto, Sabino Front Cardiovasc Med Cardiovascular Medicine OBJECTIVES: To assess the impact of conventional transcatheter heart valve (THV) commissural alignment techniques on THV/coronary overlap and coronary access (CA) after transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BAV). BACKGROUND: Specific Evolut Pro/Pro + and Acurate Neo2 THV orientations are associated with reduced neo-commissural overlap with coronary ostia in tricuspid aortic anatomy. Whether standard orientation techniques are effective also in the setting of BAV anatomy has not been studied. METHODS: The DA VINCI (Definition of trAnscatheter aortic Valve orIeNtation in biCuspId aortic valve) pilot study is a prospective registry enrolling consecutive patients with severe BAV stenosis undergoing TAVR with last generation supra-annular tall-frame THVs implanted with a cusp overlap view-based commissural alignment. Patients underwent pre- and post-TAVR computed tomography (CT) and coronary angiography. The study endpoint was the rate of favorable THV/coronary overlap, defined as an angle > 40° between the THV commissural post and coronary ostia. Other endpoints were the rates of successful THV alignment with respect to the raphe and of selective CA after TAVR. Moreover, different virtual THV alignment models were tested to identify which one would produce the lower degree of THV/coronary overlap. RESULTS: Thirty-four patients with type 1 BAV with right-left raphe undergoing TAVR (23 with Evolut Pro/Pro + and 11 with Acurate Neo2) were included. At pre-TAVR CT, moderate/severe cusp asymmetry was found in 50% of patients, severe coronary ostia eccentricity was observed in 47.1% for the RCA vs. 8.8% for the LCA (P < 0.007). Correct TVH orientation was achieved in 29 cases. At post-TAVR CT, optimal THV alignment/mild misalignment to the raphe was observed in 86.2%, but a moderate/severe overlap with the coronaries was seen in 13.7% for the RCA and 44.8% for the LCA (P = 0.019). After TAVR, selective RCA cannulation was possible in 82.8% vs. 75.9% for the LCA (P = 0.74), while combined selective CA of both coronaries was possible in less than two-thirds of the patients. Virtual THV alignment in the coronary ostia overlap view assuming a hypothetical circular THV expansion would produce an optimal THV/coronary overlap in almost 90% of cases. CONCLUSION: Given cusp asymmetry and coronary ostia eccentricity of BAV combined with potential THV asymmetrical expansion, conventional commissural alignment techniques are associated with higher rates of THV misalignment and of moderate/severe neo-commissure overlap with the coronary ostia as compared to tricuspid aortic stenosis, resulting in lower rates of selective CA after TAVR. A modified THV orientation technique based on the coronary ostia overlap view might be preferable in BAV patients. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9790995/ /pubmed/36578836 http://dx.doi.org/10.3389/fcvm.2022.1056496 Text en Copyright © 2022 Tarantini, Fabris, Nai Fovino, Cardaioli, Pergola, Montonati, Rodinò, Cabrelle, Massussi, Scotti, Zuccarelli, Sciarretta, Masiero, Gregori, Napodano, Fraccaro, Continisio and Iliceto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Tarantini, Giuseppe
Fabris, Tommaso
Nai Fovino, Luca
Cardaioli, Francesco
Pergola, Valeria
Montonati, Carolina
Rodinò, Giulio
Cabrelle, Giulio
Massussi, Mauro
Scotti, Andrea
Zuccarelli, Vittorio
Sciarretta, Tommaso
Masiero, Giulia
Gregori, Dario
Napodano, Massimo
Fraccaro, Chiara
Continisio, Saverio
Iliceto, Sabino
Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title_full Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title_fullStr Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title_full_unstemmed Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title_short Definition of trAnscatheter heart Valve orIeNtation in biCuspId aortic valve: The DA VINCI pilot study
title_sort definition of transcatheter heart valve orientation in bicuspid aortic valve: the da vinci pilot study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790995/
https://www.ncbi.nlm.nih.gov/pubmed/36578836
http://dx.doi.org/10.3389/fcvm.2022.1056496
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