Contribution of integrin adhesion to cytokinetic abscission and genomic integrity

Recent research shows that integrin-mediated adhesion contributes to the regulation of cell division at two key steps: the formation of the mitotic spindle at the mitotic entry and the final cytokinetic abscission at the mitotic exit. Failure in either of these processes will have a direct impact on...

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Autores principales: Rani, Bhavna, Gupta, Deepesh K., Johansson, Staffan, Kamranvar, Siamak A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791049/
https://www.ncbi.nlm.nih.gov/pubmed/36578785
http://dx.doi.org/10.3389/fcell.2022.1048717
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author Rani, Bhavna
Gupta, Deepesh K.
Johansson, Staffan
Kamranvar, Siamak A.
author_facet Rani, Bhavna
Gupta, Deepesh K.
Johansson, Staffan
Kamranvar, Siamak A.
author_sort Rani, Bhavna
collection PubMed
description Recent research shows that integrin-mediated adhesion contributes to the regulation of cell division at two key steps: the formation of the mitotic spindle at the mitotic entry and the final cytokinetic abscission at the mitotic exit. Failure in either of these processes will have a direct impact on the other in each round of the cell cycle and on the genomic integrity. This review aims to present how integrin signals are involved at these cell cycle stages under normal conditions and some safety mechanisms that may counteract the generation of aneuploid cells in cases of defective integrin signals.
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spelling pubmed-97910492022-12-27 Contribution of integrin adhesion to cytokinetic abscission and genomic integrity Rani, Bhavna Gupta, Deepesh K. Johansson, Staffan Kamranvar, Siamak A. Front Cell Dev Biol Cell and Developmental Biology Recent research shows that integrin-mediated adhesion contributes to the regulation of cell division at two key steps: the formation of the mitotic spindle at the mitotic entry and the final cytokinetic abscission at the mitotic exit. Failure in either of these processes will have a direct impact on the other in each round of the cell cycle and on the genomic integrity. This review aims to present how integrin signals are involved at these cell cycle stages under normal conditions and some safety mechanisms that may counteract the generation of aneuploid cells in cases of defective integrin signals. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791049/ /pubmed/36578785 http://dx.doi.org/10.3389/fcell.2022.1048717 Text en Copyright © 2022 Rani, Gupta, Johansson and Kamranvar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rani, Bhavna
Gupta, Deepesh K.
Johansson, Staffan
Kamranvar, Siamak A.
Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title_full Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title_fullStr Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title_full_unstemmed Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title_short Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
title_sort contribution of integrin adhesion to cytokinetic abscission and genomic integrity
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791049/
https://www.ncbi.nlm.nih.gov/pubmed/36578785
http://dx.doi.org/10.3389/fcell.2022.1048717
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