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Dual roles and potential applications of exosomes in HCV infections
The hepatitis C virus (HCV) causes severe liver diseases, including hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have high morbidity and mortality. Antibody targeting receptor-mediated HCV infections have limited therapeutic benefits, suggesting that the transmission of HCV infect...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791051/ https://www.ncbi.nlm.nih.gov/pubmed/36578571 http://dx.doi.org/10.3389/fmicb.2022.1044832 |
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author | Yin, Yiqian Zhao, Yuxue Chen, Qiaoqiao Chen, Yiwen Mao, Lingxiang |
author_facet | Yin, Yiqian Zhao, Yuxue Chen, Qiaoqiao Chen, Yiwen Mao, Lingxiang |
author_sort | Yin, Yiqian |
collection | PubMed |
description | The hepatitis C virus (HCV) causes severe liver diseases, including hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have high morbidity and mortality. Antibody targeting receptor-mediated HCV infections have limited therapeutic benefits, suggesting that the transmission of HCV infections is possibly mediated via receptor-independent mechanisms. Exosomes are membrane-enclosed vesicles with a diameter of 30–200 nm, which originate from the fusion of endosomal multivesicular bodies with the plasma membrane. Accumulating evidence suggests that exosomes have a pivotal role in HCV infections. Exosomes can transfer viral and cellular bioactive substances, including nucleic acids and proteins, to uninfected cells, thus spreading the infection by masking these materials from immunological recognition. In addition, exosomes originating from some cells can deliver antiviral molecules or prompt the immune response to inhibit HCV infection. Exosomes can be used for the diagnosis of HCV-related diseases, and are being presently evaluated as therapeutic tools for anti-HCV drug delivery. This review summarizes the current knowledge on the dual roles and potential clinical applications of exosomes in HCV infections. |
format | Online Article Text |
id | pubmed-9791051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97910512022-12-27 Dual roles and potential applications of exosomes in HCV infections Yin, Yiqian Zhao, Yuxue Chen, Qiaoqiao Chen, Yiwen Mao, Lingxiang Front Microbiol Microbiology The hepatitis C virus (HCV) causes severe liver diseases, including hepatitis, liver cirrhosis, and hepatocellular carcinoma, which have high morbidity and mortality. Antibody targeting receptor-mediated HCV infections have limited therapeutic benefits, suggesting that the transmission of HCV infections is possibly mediated via receptor-independent mechanisms. Exosomes are membrane-enclosed vesicles with a diameter of 30–200 nm, which originate from the fusion of endosomal multivesicular bodies with the plasma membrane. Accumulating evidence suggests that exosomes have a pivotal role in HCV infections. Exosomes can transfer viral and cellular bioactive substances, including nucleic acids and proteins, to uninfected cells, thus spreading the infection by masking these materials from immunological recognition. In addition, exosomes originating from some cells can deliver antiviral molecules or prompt the immune response to inhibit HCV infection. Exosomes can be used for the diagnosis of HCV-related diseases, and are being presently evaluated as therapeutic tools for anti-HCV drug delivery. This review summarizes the current knowledge on the dual roles and potential clinical applications of exosomes in HCV infections. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791051/ /pubmed/36578571 http://dx.doi.org/10.3389/fmicb.2022.1044832 Text en Copyright © 2022 Yin, Zhao, Chen, Chen and Mao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Yin, Yiqian Zhao, Yuxue Chen, Qiaoqiao Chen, Yiwen Mao, Lingxiang Dual roles and potential applications of exosomes in HCV infections |
title | Dual roles and potential applications of exosomes in HCV infections |
title_full | Dual roles and potential applications of exosomes in HCV infections |
title_fullStr | Dual roles and potential applications of exosomes in HCV infections |
title_full_unstemmed | Dual roles and potential applications of exosomes in HCV infections |
title_short | Dual roles and potential applications of exosomes in HCV infections |
title_sort | dual roles and potential applications of exosomes in hcv infections |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791051/ https://www.ncbi.nlm.nih.gov/pubmed/36578571 http://dx.doi.org/10.3389/fmicb.2022.1044832 |
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