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Advances in Stigmasterol on its anti-tumor effect and mechanism of action

Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs, soybean and tobacco, and it has received much attention for its various pharmacological effects including anti-inflammation, anti-diabetes, anti-oxidization, and lowering blood cholesterol. Multiple studies have rev...

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Autores principales: Zhang, Xiaoyu, Wang, Jiayun, Zhu, Lin, Wang, Xuezhen, Meng, Feifei, Xia, Lei, Zhang, Hairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791061/
https://www.ncbi.nlm.nih.gov/pubmed/36578938
http://dx.doi.org/10.3389/fonc.2022.1101289
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author Zhang, Xiaoyu
Wang, Jiayun
Zhu, Lin
Wang, Xuezhen
Meng, Feifei
Xia, Lei
Zhang, Hairong
author_facet Zhang, Xiaoyu
Wang, Jiayun
Zhu, Lin
Wang, Xuezhen
Meng, Feifei
Xia, Lei
Zhang, Hairong
author_sort Zhang, Xiaoyu
collection PubMed
description Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs, soybean and tobacco, and it has received much attention for its various pharmacological effects including anti-inflammation, anti-diabetes, anti-oxidization, and lowering blood cholesterol. Multiple studies have revealed that stigmasterol holds promise as a potentially beneficial therapeutic agent for malignant tumors because of its significant anti-tumor bioactivity. It is reported that stigmasterol has anti-tumor effect in a variety of malignancies (e.g., breast, lung, liver and ovarian cancers) by promoting apoptosis, inhibiting proliferation, metastasis and invasion, and inducing autophagy in tumor cells. Mechanistic study shows that stigmasterol triggers apoptosis in tumor cells by regulating the PI3K/Akt signaling pathway and the generation of mitochondrial reactive oxygen species, while its anti-proliferative activity is mainly dependent on its modulatory effect on cyclin proteins and cyclin-dependent kinase (CDK). There have been multiple mechanisms underlying the anti-tumor effect of stigmasterol, which make stigmasterol promising as a new anti-tumor agent and provide insights into research on its anti-tumor role. Presently, stigmasterol has been poorly understood, and there is a paucity of systemic review on the mechanism underlying its anti-tumor effect. The current study attempts to conduct a literature review on stigmasterol for its anti-tumor effect to provide reference for researchers and clinical workers.
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spelling pubmed-97910612022-12-27 Advances in Stigmasterol on its anti-tumor effect and mechanism of action Zhang, Xiaoyu Wang, Jiayun Zhu, Lin Wang, Xuezhen Meng, Feifei Xia, Lei Zhang, Hairong Front Oncol Oncology Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs, soybean and tobacco, and it has received much attention for its various pharmacological effects including anti-inflammation, anti-diabetes, anti-oxidization, and lowering blood cholesterol. Multiple studies have revealed that stigmasterol holds promise as a potentially beneficial therapeutic agent for malignant tumors because of its significant anti-tumor bioactivity. It is reported that stigmasterol has anti-tumor effect in a variety of malignancies (e.g., breast, lung, liver and ovarian cancers) by promoting apoptosis, inhibiting proliferation, metastasis and invasion, and inducing autophagy in tumor cells. Mechanistic study shows that stigmasterol triggers apoptosis in tumor cells by regulating the PI3K/Akt signaling pathway and the generation of mitochondrial reactive oxygen species, while its anti-proliferative activity is mainly dependent on its modulatory effect on cyclin proteins and cyclin-dependent kinase (CDK). There have been multiple mechanisms underlying the anti-tumor effect of stigmasterol, which make stigmasterol promising as a new anti-tumor agent and provide insights into research on its anti-tumor role. Presently, stigmasterol has been poorly understood, and there is a paucity of systemic review on the mechanism underlying its anti-tumor effect. The current study attempts to conduct a literature review on stigmasterol for its anti-tumor effect to provide reference for researchers and clinical workers. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791061/ /pubmed/36578938 http://dx.doi.org/10.3389/fonc.2022.1101289 Text en Copyright © 2022 Zhang, Wang, Zhu, Wang, Meng, Xia and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Xiaoyu
Wang, Jiayun
Zhu, Lin
Wang, Xuezhen
Meng, Feifei
Xia, Lei
Zhang, Hairong
Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title_full Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title_fullStr Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title_full_unstemmed Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title_short Advances in Stigmasterol on its anti-tumor effect and mechanism of action
title_sort advances in stigmasterol on its anti-tumor effect and mechanism of action
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791061/
https://www.ncbi.nlm.nih.gov/pubmed/36578938
http://dx.doi.org/10.3389/fonc.2022.1101289
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