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Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4(+) T Cells Ameliorates Intestinal Inflammation

BACKGROUND & AIMS: Despite recent evidence supporting the metabolic plasticity of CD4(+) T cells, it is uncertain whether the metabolic checkpoint pyruvate dehydrogenase kinase (PDK) in T cells plays a role in the pathogenesis of colitis. METHODS: To investigate the role of PDK4 in colitis, we u...

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Detalles Bibliográficos
Autores principales:	Lee, Hoyul, Jeon, Jae Han, Lee, Yu-Jeong, Kim, Mi-Jin, Kwon, Woong Hee, Chanda, Dipanjan, Thoudam, Themis, Pagire, Haushabhau S., Pagire, Suvarna H., Ahn, Jin Hee, Harris, Robert A., Kim, Eun Soo, Lee, In-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791136/ https://www.ncbi.nlm.nih.gov/pubmed/36229019 http://dx.doi.org/10.1016/j.jcmgh.2022.09.016

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