Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria

A 39-year-old woman with biochemically and clinically active acute intermittent porphyria (AIP) developed moderately severe liver injury after receiving her second dose of givosiran. Serologic evaluation ruled out hepatitis caused by viral, autoimmune, or other metabolic etiologies. The updated Rous...

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Detalles Bibliográficos
Autores principales: Ma, Christopher D., Faust, Denise, Bonkovsky, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791166/
https://www.ncbi.nlm.nih.gov/pubmed/36578356
http://dx.doi.org/10.1016/j.ymgmr.2022.100946
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author Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
author_facet Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
author_sort Ma, Christopher D.
collection PubMed
description A 39-year-old woman with biochemically and clinically active acute intermittent porphyria (AIP) developed moderately severe liver injury after receiving her second dose of givosiran. Serologic evaluation ruled out hepatitis caused by viral, autoimmune, or other metabolic etiologies. The updated Roussel Uclaf Causality Assessment Method (RUCAM) score was 8 and the Revised Electronic Causality Assessment Method (RECAM) score for givosiran was 9. Results of liver tests returned to normal after givosiran was discontinued, and she has not received any more givosiran.
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spelling pubmed-97911662022-12-27 Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria Ma, Christopher D. Faust, Denise Bonkovsky, Herbert L. Mol Genet Metab Rep Short Communication A 39-year-old woman with biochemically and clinically active acute intermittent porphyria (AIP) developed moderately severe liver injury after receiving her second dose of givosiran. Serologic evaluation ruled out hepatitis caused by viral, autoimmune, or other metabolic etiologies. The updated Roussel Uclaf Causality Assessment Method (RUCAM) score was 8 and the Revised Electronic Causality Assessment Method (RECAM) score for givosiran was 9. Results of liver tests returned to normal after givosiran was discontinued, and she has not received any more givosiran. Elsevier 2022-12-15 /pmc/articles/PMC9791166/ /pubmed/36578356 http://dx.doi.org/10.1016/j.ymgmr.2022.100946 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Ma, Christopher D.
Faust, Denise
Bonkovsky, Herbert L.
Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title_full Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title_fullStr Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title_full_unstemmed Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title_short Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
title_sort idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791166/
https://www.ncbi.nlm.nih.gov/pubmed/36578356
http://dx.doi.org/10.1016/j.ymgmr.2022.100946
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AT bonkovskyherbertl idiosyncraticdruginducedliverinjurycausedbygivosiraninapatientwithacuteintermittentporphyria

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