DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 Axis

BACKGROUND & AIMS: Gastrointestinal cancer stem cell marker doublecortin-like kinase (DCLK1) is strongly associated with poor outcomes in colorectal cancer (CRC). Although DCLK1’s regulatory effect on the tumor immune microenvironment has been hypothesized, its mode of action has not been shown...

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Detalles Bibliográficos
Autores principales: Yan, Rui, Li, Jianjian, Xiao, Zeru, Fan, Xiaona, Liu, Heshu, Xu, Ying, Sun, Ruya, Liu, Jian, Yao, Jiannan, An, Guangyu, Shi, Yan, Ge, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791173/
https://www.ncbi.nlm.nih.gov/pubmed/36309200
http://dx.doi.org/10.1016/j.jcmgh.2022.10.013

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