Cargando…
Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission
INTRODUCTION: Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. METHODS: In this study, we evaluated Fc receptor engagement and ADCC activity of...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791209/ https://www.ncbi.nlm.nih.gov/pubmed/36578481 http://dx.doi.org/10.3389/fimmu.2022.1051501 |
_version_ | 1784859352048336896 |
---|---|
author | Barrows, Brittani M. Krebs, Shelly J. Jian, Ningbo Zemil, Michelle Slike, Bonnie M. Dussupt, Vincent Tran, Ursula Mendez-Rivera, Letzibeth Chang, David O’Sullivan, Anne Marie Mann, Brendan Sanders-Buell, Eric Shubin, Zhanna Creegan, Matt Paquin-Proulx, Dominic Ehrenberg, Philip Laurence-Chenine, Agnes Srithanaviboonchai, Kriengkrai Thomas, Rasmi Eller, Michael A. Ferrari, Guido Robb, Merlin Rao, Venigalla Tovanabutra, Sodsai Polonis, Victoria R. Wieczorek, Lindsay |
author_facet | Barrows, Brittani M. Krebs, Shelly J. Jian, Ningbo Zemil, Michelle Slike, Bonnie M. Dussupt, Vincent Tran, Ursula Mendez-Rivera, Letzibeth Chang, David O’Sullivan, Anne Marie Mann, Brendan Sanders-Buell, Eric Shubin, Zhanna Creegan, Matt Paquin-Proulx, Dominic Ehrenberg, Philip Laurence-Chenine, Agnes Srithanaviboonchai, Kriengkrai Thomas, Rasmi Eller, Michael A. Ferrari, Guido Robb, Merlin Rao, Venigalla Tovanabutra, Sodsai Polonis, Victoria R. Wieczorek, Lindsay |
author_sort | Barrows, Brittani M. |
collection | PubMed |
description | INTRODUCTION: Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. METHODS: In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission. RESULTS: HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV. DISCUSSION: This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity. |
format | Online Article Text |
id | pubmed-9791209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97912092022-12-27 Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission Barrows, Brittani M. Krebs, Shelly J. Jian, Ningbo Zemil, Michelle Slike, Bonnie M. Dussupt, Vincent Tran, Ursula Mendez-Rivera, Letzibeth Chang, David O’Sullivan, Anne Marie Mann, Brendan Sanders-Buell, Eric Shubin, Zhanna Creegan, Matt Paquin-Proulx, Dominic Ehrenberg, Philip Laurence-Chenine, Agnes Srithanaviboonchai, Kriengkrai Thomas, Rasmi Eller, Michael A. Ferrari, Guido Robb, Merlin Rao, Venigalla Tovanabutra, Sodsai Polonis, Victoria R. Wieczorek, Lindsay Front Immunol Immunology INTRODUCTION: Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. METHODS: In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission. RESULTS: HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV. DISCUSSION: This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity. Frontiers Media S.A. 2022-12-12 /pmc/articles/PMC9791209/ /pubmed/36578481 http://dx.doi.org/10.3389/fimmu.2022.1051501 Text en Copyright © 2022 Barrows, Krebs, Jian, Zemil, Slike, Dussupt, Tran, Mendez-Rivera, Chang, O’Sullivan, Mann, Sanders-Buell, Shubin, Creegan, Paquin-Proulx, Ehrenberg, Laurence-Chenine, Srithanaviboonchai, Thomas, Eller, Ferrari, Robb, Rao, Tovanabutra, Polonis and Wieczorek https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Barrows, Brittani M. Krebs, Shelly J. Jian, Ningbo Zemil, Michelle Slike, Bonnie M. Dussupt, Vincent Tran, Ursula Mendez-Rivera, Letzibeth Chang, David O’Sullivan, Anne Marie Mann, Brendan Sanders-Buell, Eric Shubin, Zhanna Creegan, Matt Paquin-Proulx, Dominic Ehrenberg, Philip Laurence-Chenine, Agnes Srithanaviboonchai, Kriengkrai Thomas, Rasmi Eller, Michael A. Ferrari, Guido Robb, Merlin Rao, Venigalla Tovanabutra, Sodsai Polonis, Victoria R. Wieczorek, Lindsay Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title | Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title_full | Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title_fullStr | Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title_full_unstemmed | Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title_short | Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission |
title_sort | fc receptor engagement of hiv-1 env-specific antibodies in mothers and infants predicts reduced vertical transmission |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791209/ https://www.ncbi.nlm.nih.gov/pubmed/36578481 http://dx.doi.org/10.3389/fimmu.2022.1051501 |
work_keys_str_mv | AT barrowsbrittanim fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT krebsshellyj fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT jianningbo fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT zemilmichelle fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT slikebonniem fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT dussuptvincent fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT tranursula fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT mendezriveraletzibeth fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT changdavid fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT osullivanannemarie fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT mannbrendan fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT sandersbuelleric fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT shubinzhanna fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT creeganmatt fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT paquinproulxdominic fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT ehrenbergphilip fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT laurencechenineagnes fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT srithanaviboonchaikriengkrai fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT thomasrasmi fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT ellermichaela fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT ferrariguido fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT robbmerlin fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT raovenigalla fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT tovanabutrasodsai fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT polonisvictoriar fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission AT wieczoreklindsay fcreceptorengagementofhiv1envspecificantibodiesinmothersandinfantspredictsreducedverticaltransmission |